Professor Lawrence Que, Jr.  
Regents Photo Que
  • B.S. 1969 Ateneo de Manila University

  • Ph.D. 1973 University of Minnesota under Professor Louis H. Pignolet

  • Postdoctoral Research under Professor Richard H. Holm at M.I.T. and under Professor Eckard Münck at the University of Minnesota

  • 1977-1983: Cornell University
  • 1983-present: University of Minnesota

  • 1999 3M/Alumni Distinguished Professor of Chemistry

  • 2000 Distinguished Teaching Professor

  • 2009 Regents Professor


HONORS AND AWARDS
  • 2001 Fellow of the American Association for the Advancement of Science

  • 2005 Frontiers in Biological Chemistry Award from the Max-Planck-Institut für Bioanorganishe Chemie

  • 2008 American Chemical Society Alfred Bader Award in Bioorganic or Bioinorganic Chemistry

  • 2008 Fellow of the Royal Society of Chemistry

  • 2011 Royal Society of Chemistry Inorganic Reaction Mechanisms Award

  • 2011 American Chemistry Society Fellow

  • 2012 Bailar Medal

  • 2015 Japan Society of Coordination Chemistry (JSCC) International Award

  • 2017 American Chemical Society Award in Inorganic Chemistry

 

 

 

Publications
[2010]
[2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002]
[2001] [ 2000] [1999] [1998] [1997] [1996] [1990-1992] [1989-1990]

 

 

2017

Bigelow, J. O.; England, J.; Klein, J. E. M. N.; Farquhar, E. R.; Frisch, J. R.; Martinho, M.; Mandal, D.; Münck, E.; Shaik, S.; Que, L., Jr., Oxoiron(IV) Tetramethylcyclam Complexes with Axial Carboxylate Ligands: Effect of Tethering the Carboxylate on Reactivity. Inorg. Chem. 2017, 56, 3287-3301 (DOI: 10.1021/acs.inorgchem.6b02659, PMC5293164, NIH ). Article

Draksharapu, A.; Rasheed, W.; Klein, J. E. M. N.; Que, L., Jr.. Facile and Reversible Formation of Fe(III)–O–Ce(IV) Species from the Reactions of Nonheme Oxoiron(IV) Complexes with Ce(III). Angew. Chem. Int. Ed., 2017 (DOI: 10.1002/anie.201704322, NIH). Article

Jasniewski, A. J.; Komor, A. J.; Lipscomb, J. D.; Que, L., Jr., An Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI  J. Am. Chem. Soc. 2017, 139, 10472-10485 (DOI: 10.1021/jacs.7b05389, PMC5568637, NIH). Article

Kal, S. & Que, L. Dioxygen Activation by Nonheme Iron Enzymes with the 2-His-1-carboxylate Facial Triad that Generate High-valent Oxoiron Oxidants. J. Biol. Inorg. Chem. 2017, 22:2.(DOI: 10.1007/s00775-016-1431-2,, NSF). Article

Pattanayak, S.; Jasniewski, A. J.; Rana, A.; Draksharapu, A.; Singh, K. K.; Weitz, A.; Hendrich, M.; Que, L., Jr.; Dey, A.; Gupta, S. S., Spectroscopic and Reactivity Comparisons of a Pair of bTAML Complexes with FeV=O and FeIV=O Units Inorg. Chem. 2017, 56, 6352-6361 (DOI: 10.1021/acs.inorgchem.7b00448, NSF). Article

Verma, P.; Varga, Z.; Klein, J. E. M. N.; Cramer, C. J.; Que, L., Jr.; Truhlar, D. G., Assessment of Electronic Structure Methods for the Determination of the Ground Spin States of Fe(II), Fe(III) and Fe(IV) Complexes. Phys. Chem. Chem. Phys. 2017, 19, 13049-13069 (DOI: 10.1039/C7CP01263B, NSF). Article

Zhou, A.; Prakash, J.; Rohde, G. T.; Klein, J. E. M. N.; Kleespies, S. T.; Draksharapu, A.; Fan, R.; Guo, Y.; Cramer, C. J.; Que, L., Jr., The Two Faces of Tetramethylcyclam in Iron Chemistry: Distinct Fe–O–M Complexes Derived from [FeIV(Oanti/syn)(TMC)]2+ Isomers. Inorg. Chem. 2017, 56, 518-527 (DOI: 10.1021/acs.inorgchem.6b02417; PMC5293164, NIH). Article

 

2016

Bucinsky, L.; Rohde, G. T.; Que, L., Jr.; Ozarowski, A.; Krzystek, J.; Breza, M.; Telser, J., HFEPR and Computational Studies on the Electronic Structure of a High-Spin Oxidoiron(IV) Complex in Solution. Inorg. Chem. 2016, 55, 3933−3945 (DOI: 10.1021/acs.inorgchem.6b00169). Article

Jasniewski, A. J.; Engstrom, L. M.; Vu, V. V.; Park, M. H.; Que, L., Jr., X-ray Absorption Spectroscopic Characterization of the Diferric-peroxo Intermediate of Human Deoxyhypusine Hydroxylase in the Presence of its Substrate eIF5a. J. Biol. Inorg. Chem. 2016, 21.(DOI: 10.1007/s00775-016-1373-8; PMCID: PMC4990465). Article

Jasniewski, A. J.; Knoot, C. J.; Lipscomb, J. D.; Que, L., Jr., A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase. Biochemistry 2016, 55, 5818–5831 (DOI: 10.1021/acs.biochem.6b00834; PMC4567504). Article

Klein, J.E.M.N.; Que, L., Jr. "Biomimetic High-Valent Mononuclear Nonheme Iron-Oxo Chemistry."In Encyclopedia of Inorganic and Bioinorganic Chemistry, ed. R.A. Scott, John Wiley, Chichester. (DOI: 10.1002/9781119951438.eibc2344; published 08 March 2016.)

Klein, J. E. M. N.; Dereli, B.; Que, L., Jr.; Cramer, C. J., Why Metal-Oxos React with Dihydroanthracene and Cyclohexadiene at Comparable Rates, Despite Having Different C–H Bond Strengths. A Computational Study. Chem. Commun. 2016, 55, 10509-10512 (DOI: 10.1039/c6cc05395e, NSF). Article

Komor, A. J.; Rivard, B. S.; Fan, R.; Guo, Y.; Que, L., Jr.; Lipscomb, J. D., Mechanism for Six-Electron Aryl-N-oxygenation by the Non-Heme Diiron Enzyme CmlI. J. Am. Chem. Soc. 2016, 138, 7411–7421 (DOI: 10.1021/jacs.6b03341). Article

Prakash, J.; Que, L., Jr., Formation of the syn Isomer of [FeIV(Oanti)(TMC)(NCMe)]2+ in the Reaction of Lewis Acids with the Side-on Bound Peroxo Ligand in [FeIII(η2–O2)(TMC)]+. Chem. Commun. 2016, 55, 8146-8148 (DOI: 10.1039/C6CC01660J). Article

Puri, M.; Biswas, A. N.; Fan, R.; Guo, Y.; Que, L., Jr. Modeling Non-Heme Iron Halogenases: High-Spin Oxoiron(IV)−Halide Complexes That Halogenate C−H Bonds. J. Am. Chem. Soc. 2016, 138, 2484-2487 (DOI: 10.1021/jacs.5b11511). Article

Puri, M.; Company, A.; Sabenya, G.; Costas, M.; Que, L., Jr., Oxygen-Atom Exchange Between H2O and Nonheme Oxoiron(IV) Complexes: Ligand Dependence and Mechanism. Inorg. Chem. 2016, 55, 5818-5827 (DOI: 10.1021/acs.inorgchem.6b00023). Article

Que, L., Jr.; Puri, M., The Amazing High-Valent Nonheme Iron-Oxo Landscape. Bull. Jpn. Soc. Coord. Chem. 2016. 67, 10-18.

Stout, H. D.; Kleespies, S. T.; Chiang, C.-W.; Lee, W.-Z.; Que, L., Jr.; Münck, E.; Bominaar, E., Spectroscopic and Theoretical Study of Spin-dependent Electron Transfer in an FeIII-Superoxo Complex. Inorg. Chem. 2016, 55, 5215–5226 (DOI: 10.1021/acs.inorgchem.6b00134). Article

Sutherlin, K. D.; Liu, L. V.; Lee, Y.-M.; Kwak, Y.; Yoda, Y.; Saito, M.; Kurokuzu, M.; Kobayashi, Y.; Seto, M.; Que, L., Jr.; Nam, W.; Solomon, E. I., Nuclear Resonance Vibrational Spectroscopic Definition of Peroxy Intermediates in Nonheme Iron Sites. J. Am. Chem. Soc. 2016, 138, 14294–14302 (DOI: 10.1021/ja960741t, NSF). Article

 

2015

Allpress, C. J; Kleespies, S. T.; Que, L., Jr., "Synthetic Models of 2-Oxoglutarate-Dependent Oxygenases." In 2-Oxoglutarate-Dependent Oxygenases, eds. C.J. Schofield and R.P. Hausinger, Royal Society of Chemistry, Cambridge, 2015.

Biswas, A. N.; Puri, M.; Meier, K. K.; Oloo, W. N.; Rohde, G. T.; Bominaar, E. L.; Münck, E.; Que, L., Jr., Modeling TauD-J: A High-Spin Nonheme Oxoiron(IV) Complex with High Reactivity Toward C–H Bonds. J. Am. Chem. Soc. 2015, 137, 2428-2431 (DOI: 10.1021/ja511757j). Article

Codolà, Z.; Gómez, L.; Kleespies, S. T.; Que Jr, L.; Costas, M.; Lloret-Fillol, J., Evidence for an Oxygen Evolving Iron–oxo–cerium Intermediate in Iron-catalysed Water Oxidation. Nat. Commun. 2015, 6, 645 (DOI:10.1038/comms6865; PMC4722336). Article

England, J.; Prakash, J.; Cranswick, M. A.; Mandal, D.; Guo, Y.; Münck, E.; Shaik, S.; Que, L., Jr., Oxoiron(IV) Complex of the Ethylene-Bridged Dialkylcyclam Ligand Me2EBC. Inorg. Chem. 2015, 54, 7828-7839 (DOI:10.1021/acs.inorgchem.5b00861). Article

de Sousa, D. P.; Bigelow, J. O.; Sundberg, J.; Que, L.; McKenzie, C. J., Caught! Crystal Trapping of a Side-on Peroxo Bound to Cr(IV). Chem. Commun. 2015, 51, 2802-2805 (DOI: 10.1039/C4CC08785B). Article

Kleespies, S. T.; Oloo, W. N.; Mukherjee, A.; Que, L., Jr., C–H Bond Cleavage by Bioinspired Nonheme Oxoiron(IV) Complexes, Including Hydroxylation of n-Butane. Inorg. Chem. 2015, Jun 1;54(11):5053-64. (DOI: 10.1021/ic502786y). Article

Makris, T. M.; Vu, V. V.; Meier, K. K.; Komor, A. J.; Rivard, B. S.; Münck, E.; Que, L., Jr.; Lipscomb, J. D., An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway. J. Am. Chem. Soc. 2015, 137, 1608-1617 (DOI: 10.1021/ja511649n; PMC4318726). Article

Oloo, W. N.; Que, L., Jr. Bio-inspired Nonheme Iron Catalysts for C–H and C=C Bond Oxidation: Insights into the Nature of the Metal-Based Oxidants. Acc. Chem. Res. 2015, 48, 2612-2621.(DOI: 10.1021/acs.accounts.5b00053.) Article

Prakash, J.; Rohde, G. T.; Meier, K. K.; Jasniewski, A. J.; Heuvelen, K. M. V.; Münck, E.; Que, L., Jr., Spectroscopic Identification of FeIII (and not FeIV) in the Crystalline Adduct Formed from [FeIV(O)(TMC)(NCMe)]2+. J. Am. Chem. Soc. 2015, 137, 3478-3481 (DOI: 10.1021/jacs.5b00535; PMC4939224). Article

Prakash, J.; Rohde, G. T.; Meier, K. K.; Münck, E.; Que, L., Jr., Upside Down! Crystallographic and Spectroscopic Characterization of an [FeIV(Osyn)(TMC)]2+ Complex. Inorg. Chem. 2015, 54, 11055-11057 (DOI:10.1021/acs.inorgchem.5b02011). Article

Puri, M.; Que, L., Jr. Toward the Synthesis of More Reactive S = 2 Non-Heme Oxoiron(IV) Complexes. Acc. Chem. Res. 2015, 48, 2443-2452 (DOI: 10.1021/acs.accounts.5b00244; PMC4542507). Article

Serrano-Plana, J.; Oloo, W. N.; Acosta-Rueda, L.; Meier, K. K.; Verdejo, B.; García-España, E.; Basallote, M. G.; Münck, E.; Que, L., Jr.; Company, A.; Costas, M. Trapping a Highly Reactive Non-heme Iron Intermediate That Oxygenates Strong C-H Bonds with Stereoretention. J. Am. Chem. Soc. 2015, 137, 15833-15842.(DOI:10.1021/jacs.5b09904). Article

Schreiber,R. E.; Cohen, H.; Leitus, G.; Wolf, S. G.; Ang Zhou, A.; Que, L., Jr.; Neumann, R. Reactivity and O2 Formation by Mn(IV)- and Mn(V)-Hydroxo Species Stabilized within a Polyfluoroxometalate Framework. J. Am. Chem. Soc. 2015, 137, 8738-8748. (DOI: 10.1021/jacs.5b03456; PMCID: PMC4939246). Article

Shokri, A.; Que, L., Jr. Conversion of Aldehyde to Alkane by a Peroxoiron(III) Complex, a Functional Model for the Cyanobacterial Aldehyde Deformylating Oxygenase. J. Am. Chem. Soc. 2015, 137, 7686-7691 (DOI: 10.1021/jacs.5b01053; PMC4722334). Article

Ye, S.; Xue, G.; Krivokapic, I.; Petrenko, T.; Bill, E.; Que, L., Jr.; Neese, F., Magnetic Circular Dichroism and Computational Study of Mononuclear and Dinuclear Iron(IV) Complexes. Chem. Sci. 2015, 6, 2909-2921 (DOI: 10.1039/C4SC03268C; PMC4583211). Article

Zhou, A.; Kleespies, S. T.; Van Heuvelen, K. M.; Que, L., Jr. Characterization of a Heterobimetallic Nonheme Fe(III)–O–Cr(III) Species Formed by O2 Activation. Chem. Commun. 2015, 54, 14326-14329 (DOI: 10.1039/C5CC05931C; PMC4567504). Article

 

2014


Chiang, C.-W.; Kleespies, S. T.; Stout, H. D.; Meier, K. K.; Li, P.-Y.; Bominaar, E. L.; Que, L., Jr.; Münck, E.; Lee, W.-Z., Characterization of a Paramagnetic Mononuclear Nonheme Iron-Superoxo Complex. J. Am. Chem. Soc. 2014, 136, 10846–10849 (DOI: 10.1021/ja504410s; PMC4132977). Article

Company, A.; Sabenya, G.; González-Béjar, M.; Gómez, L.; Clémancey, M.; Blondin, G.; Jasniewski, A. J.; Puri, M.; Browne, W. R.; Latour, J.-M.; Que, L., Jr.; Costas, M.; Pérez-Prieto, J.; Lloret-Fillol, J., Triggering the Generation of an Iron(IV)-Oxo Compound and Its Reactivity toward Sulfides by RuII Photocatalysis. J. Am. Chem. Soc. 2014, 136, 4624-4633 (DOI: 10.1021/ja412059c; PMC3985778 ). Article

England, J.; Bigelow, J. O.; Heuvelen, K. M. V.; Farquhar, E. R.; Martinho, M.; Meier, K. K.; Frisch, J. R.; Münck, E.; Que, L., Jr., An Ultra-stable Oxoiron(IV) Complex and Its Blue Conjugate Base. Chem. Sci. 2014, 5, 1204-1215 (DOI: 10.1039/C3SC52755G; PMC 3956701). Article

Fielding, A. J.; Lipscomb, J. D.; Que, L., Jr., A two-electron Shell Game: intermediates of the Extradiol Cleaving Catechol Dioxygenases. J. Biol. Inorg. Chem. 2014, 19, 491-504 (DOI:10.1007/s00775-014-1122-9; PMC4039383) . Article.

Iyer, S. R.; Javadi, M. M.; Feng, Y.; Hyun, M. Y.; Oloo, W. N.; Kim, C.; Que, L., Jr., A Chameleon Catalyst forNnonheme Iron-promoted Olefin Oxidation. Chem. Commun. 2014, 50, 13777-13780 (DOI:10.1039/c4cc06164k; DOE). Article

Makhlynets, O. V.; Oloo, W.; Moroza, Y. S.; Belayaa, I. G.; Palluccio, T. D.; Filatov, A. S.; Müller, P.; Cranswick, M. A.; Que, L., Jr.; Rybak-Akimova, E. V., H2O2 Activation with Biomimetic Non-haem Iron Complexes and AcOH: Connecting the g = 2.7 EPR Signal with a Visible Chromophore. Chem. Commun. 2014, 50, 645-648 (DOI: 10.1039/C1033CC47632D). Article

Oloo, W.N.; Meier, K. K.; Wang, Y.; Shaik, S.; Münck, E.; Que, L., Jr., Identification of a Low-spin Acylperoxoiron(III) Intermediate in Bio-inspired Nonheme Iron-Catalyzed Oxidations. Nature Communications 2014, 5, 3046.(DOI: 10.1038/ncomms4046). Article

Paine, T. K.; Que, L., Jr., Dioxygen Activation by Biomimetic Iron Complexes of α-Keto Acids and α-Hydroxy Acids. Struct. Bonding 2014, 160, 39-56 (DOI:10.1007/430_2014_144). Article

Stoian, S. A.; Xue, G.; Bominaar, E. L.; Que, L., Jr.; Münck, E., Spectroscopic and Theoretical Investigation of a Complex with a [O=FeIV–O–FeIV=O] Core Related to Methane Monooxygenase Intermediate Q. J. Am. Chem. Soc. 2014, 136, 1545-1558 (DOI: 10.1021/ja411376u; PMC3941033). Article

 

2013

Frisch, J. R.; McDonnell, R.; Rybak-Akimova, E. V.; Que, L., Jr., Factors Affecting the Carboxylate Shift Upon Formation of Nonheme Diiron-O2 Adducts. Inorg. Chem. 2013, 52, 2627-36 (10.1021/ic302543n; PMCID: PMC3678525 ). Article

Hayden, J. A.; Farquhar, E. R.; Que, L., Jr.; Lipscomb, J. D.; Hendrich, M. P., NO Binding to Mn-Substituted Homoprotocatechuate 2,3-Dioxygenase and the Primary and Secondary Sphere Influences in O2 Reactivity. J. Biol. Inorg. Chem. 2013, 18, 717-728. (10.1007/s00775-013-1016-2; PMCID: PMC3936460). Article

Li, F.; Van Heuvelen, K. M.; Meier, K. K.; Münck, E.; Que, L., Sc3+-triggered Oxoiron(IV) Formation from O2 and its Nonheme Iron(II) Precursor via a Sc3+-peroxo-Fe3+ Intermediate. J. Am. Chem. Soc. 2013, 135, 10198-10201 (10.1021/ja402645y; NSF). Article

McDonald, A. R.; Que, L., Jr., High-Valent Nonheme Iron-Oxo Complexes: Synthesis, Structure, and Spectroscopy. Coord. Chem. Rev. 2013, 257, 414-428 (10.1016/j.ccr.2012.08.002). Article

Oloo, W. N.; Feng, Y.; Iyer, S.; Parmelee, S.; Xue, G.; Que, L., Jr., Cyclohexene as a Substrate Probe for the Nature of the High-valent Iron-oxo Oxidant in Fe(TPA)-catalyzed Oxidations. New. J. Chem. 2013, 37, 3411-3415 (10.1039/C3NJ00524K; DOE). Article

Oloo, W. N.; Fielding, A. J.; Que, L. J., Rate Determining Water-Assisted O–O Bond Cleavage of a FeIII–OOH Intermediate in a Bio-inspired Nonheme Iron-Catalyzed Oxidation. J. Am. Chem. Soc. 2013, 135, 6438 (doi: 10.1021/ja402759c). Article

Oloo, W. N.; Que, L., Jr., "Hydrocarbon Oxidations Catalyzed by Bio-Inspired Nonheme Iron and Copper Catalysts.” Comprehensive Inorganic Chemistry II, Vol 6; Reedijk, J., Poeppelmeier, K., Eds.; Elsevier: Oxford, 2013; pp 763-778.

Pap, J. S.; Cranswick, M. A.; Balogh-Hergovich, É.; Baráth, G.; Giorgi, M.; Rohde, G. T.; Kaizer, J.; Speier, G.; Que, L., Jr., An Iron(II)[1,3-bis(2?-pyridylimino)isoindoline] Complex as a Catalyst for Substrate Oxidation with H2O2- Evidence for a Transient Peroxidodiiron(III) Species. Eur. J. Inorg. Chem. 2013, 3858-3866 (10.1002/ejic.201300162,;PMCID: PMC3935335). Article

Park, K.; Bell, C. B., 3rd; Liu, L. V.; Wang, D.; Xue, G.; Kwak, Y.; Wong, S. D.; Light, K. M.; Zhao, J.; Alp, E. E.; Yoda, Y.; Saito, M.; Kobayashi, Y.; Ohta, T.; Seto, M.; Que, L., Jr.; Solomon, E. I., Nuclear Resonance Vibrational Spectroscopic and Computational Study of High-valent Diiron Complexes Relevant to Enzyme Intermediates. Proc. Nat. Acad. Sci. USA 2013, 110, 6275 (doi: 10.1073/pnas.1304238110; PMC3631696). Article

Prat, I.; Company, A.; Postils, V.; Ribas, X.; Que, L., Jr.; Luis, J. M.; Costas, M., The Mechanism of Stereospecific C–H Oxidation by Fe(Pytacn) Complexes: Bioinspired Non-Heme Iron Catalysts Containing cis-Labile Exchangeable Sites. Chem. Eur. J. 2013, 19, 6724 (doi: 10.1002/chem.201300110). Article

Que, L., Jr., High-Valent Nonheme Iron Oxidants in Biology: Lessons from Synthetic FeIV=O Complexes. Bull. Jpn. Soc. Coord. Chem. 2013, 62, 30-37.

Wang, D.; Que, L., Jr., Oxidation of Water by a Nonhaem Diiron(IV) Complex via Proton-coupled Electron Transfer. Chem. Commun. 2013, 49, 10682-10684 (DOI: 10.1039/c1033cc46391e; PMC3940062 ). Article

Wang, D.; Ray, K.; Collins, M. J.; Farquhar, E. R.; Frisch, J. R.; Gómez, L.; Jackson, T. A.; Kerscher, M.; Waleska, A.; Comba, P.; Costas, M.; Que, L., Jr., Nonheme Oxoiron(IV) Complexes of Pentadentate N5 Ligands: Spectroscopy, Electrochemistry, and Oxidative Reactivity. Chem. Sci. 2013, 4, 282-291 (10.1039/C2SC21318D; PMC3515645). Article

Wang, Y.; Janardanan, D.; Usharani, D.; Han, K.; Que, L., Jr.; Shaik, S., The Nonheme Iron Oxidant Formed in the Presence of H2O2 and Acetic Acid Is the Cyclic Ferric-peracetate Complex and Not a Perferryl-oxo Complex. ACS Catal. 2013, 3, 1334 (10.1021/cs400134g; DOE). Article

Xue, G.; Geng, C.; Ye, S.; Fiedler, A. T.; Neese, F.; Que, L., Jr., Hydrogen-Bonding Effects on the Reactivity of [X−FeIII−O−FeIV=O] (X = OH, F) Complexes toward C−H Bond Cleavage. Inorg. Chem. 2013, 52, 3976-3984 (doi:10.1021/ic3027896; PMC3632308). Article



2012

Cranswick, M. A.; Meier, K. K.; Shan, X.; Stubna, A.; Kaizer, J.; Mehn, M. P.; Münck, E.; Que, L., Jr,. Protonation of a Peroxodiiron(III) Complex and Conversion to a Diiron(III/IV) Intermediate: Implications for Proton-Assisted O−O Bond Cleavage in Nonheme Diiron Enzymes. Inorg. Chem. 2012, 51, 10417-10426 (10.1021/ic301642w; PMC3462276) Article

Do, L. H.; Xue, G.; Que, L., Jr.; Lippard, S. J., Evaluating the Identity and Diiron Core Transformations of a (μ-Oxo)diiron(III) Complex Supported by Electron-Rich Tris(pyridyl-2-methyl)amine Ligands. Inorg. Chem. 2012, 51, 2393-2402 (10.1021/ic202379b, PMC3288163). Article

Fielding, A. J.; Lipscomb, J. D.; Que, L. Jr., Characterization of an O2 Adduct of an Active Cobalt-Substituted Extradiol-Cleaving Catechol Dioxygenase. J. Am. Chem. Soc. 2012, 134, 796-799 (10.1021/ja2095365, PMC3262093). Article

Huo, L.; Fielding, A. J.; Chen, Y.; Li, T.; Iwaki, H.; Hosler, J. P.; Chen, L.; Hasegawa, Y.; Que, L., Jr.; Liu, A., Evidence for a Dual Role of an Active Site Histidine in α-Amino-β- Carboxymuconate-ε-Semialdehyde Decarboxylase. Biochemistry 2012, 51, 5811-5821 (10.1021/bi300635b; PMC3419591). Article

Li, F.; Chakrabarti, M.; Dong, Y.; Kauffmann, K.; Bominaar, E. L.; Münck, E.; Que, L., Jr., Structural, EPR and Mössbauer Characterization of (μ-Alkoxo)(μ-Carboxylato)Diiron(II,III) Model Complexes for the Active Sites of Mixed-valent Diiron Enzymes. Inorg. Chem. 2012, 51, 2917-29-29 (10.1021/ic2021726; PMC3298377 [Available on 2013/3/5]). Article

Mas-Ballesté, R.; McDonald, A. R.; Reed, D.; Usharani, D.; Schyman, P.; Milko, P.; Shaik, S.; Que, L., Jr., Intramolecular Gas Phase Reactions of Synthetic Non-heme Oxoiron(IV) Ions: Proximity and Spin-State Reactivity Rules. Chem. Eur. J. 2012, 18, 11747-11760 (10.1002/chem.201200105; PMC3516195). Article

McDonald, A. R.; Guo, Y.; Vu, V. V.; Bominaar, E. L.; Münck, E.; Que, L., Jr., A Mononuclear Carboxylate-Rich Oxoiron(IV) Complex: a Structural and Functional Mimic of TauD Intermediate ‘J’. Chem. Sci. 2012, 3, 1680-1683 (10.1039/C2SC01044e; PMC3528080). Article

McDonald, A. R.; Van Heuvelen, K. M..; Guo, Y.; Li, F.; Bominaar, E. L.; Münck, E.; Que, L., Jr., Characterization of a Thiolato Iron(III) Peroxy Dianion Complex. Angew. Chem. Int. Ed. 2012, 51, 9132-9136 (10.1002/anie.201203602; PMC3448492). Article

Shanmugam, M.; Xue, G.; Que, L., Jr.; Hoffman, B. M., 1H-ENDOR Evidence for a Hydrogen Bonding Interaction that Modulates the Reactivity of a Non-heme FeIV=O Unit. Inorg. Chem. 2012, 51, 10080-10082 (10.1021/ic3015783; PMC3482979). Article

Srnec, M.; Wong, S. D.; England, J.; Que, L., Jr.; Solomon, E. I., π-Frontier molecular orbitals in S = 2 Ferryl Species and Elucidation of their Contributions to Reactivity. Proc. Nat. Acad. Sci. USA 2012, 109, 14326-14331 (10.1073/pnas.1212693109; PMC3437891). Article

Van Heuvelen, K. M.; Fiedler, A. T.; Shan, X.; De Hont, R. H.; Meier, K. K.; Bominaar, E. L.; Münck, E.; Que, L., Jr., One-electron Oxidation of an Oxoiron(IV) Complex to Form an [O?FeV?NR] Center. Proc. Nat. Acad. Sci. USA 2012, 109, 11933-11938 (10.1073/pnas.1206457109; PMC3409744). Article

2011

Chandrasekaran, P.; Stieber, S. C. E.; Collins, T. J.; Que, L., Jr.; Neese, F.; DeBeer, S., Prediction of High-valent Iron K-edge Absorption Spectra by Time-dependent Density Functional Theory. Dalton Trans. 2011, 40, 11070-11079 (10.1039/c1dt11331c; PMC3242413).). [Article]

Company, A.; Prat, I.; Frisch, J. R.; Mas-Ballesté, R.; Güell, M.; Juhász, G.; Ribas, X.; Münck, E.; Luis, J. M.; Que, L., Jr.; Costas, M., Modeling the cis-Oxo-Labile Binding Site Motif of Non-Heme Iron Oxygenases: Water Exchange and Oxidation Reactivity of a Non-Heme Iron(IV)-Oxo Compound Bearing a Tripodal Tetradentate Ligand. Chem. Eur. J. 2011, 17, 1622-1634 (10.1002/chem.201002297). [Article]
 
England, J.; Farquhar, E. R.; Guo, Y.; Cranswick, M. A.; Ray, K.; Münck, E.; Que, L., Jr., Characterization of a Tricationic Trigonal Bipyramidal Iron(IV) Cyanide Complex, with a Very High Reduction Potential, and Its Iron(II) and Iron(III) Congeners. Inorg. Chem. 2011, 50, 2885–2896 (10.1021/ic102094d; PMC3065519). [Article]

England, J.; Guo, Y.; van Heuvelen, K. M.; Cranswick, M. A.; Rohde, G. T.; Bominaar, E. L.; Münck, E.; Que, L., Jr., A More Reactive Trigonal Bipyramidal High-Spin Oxoiron(IV) Complex with a cis-Labile Site. J. Am. Chem. Soc. 2011, 133, 11880–11883 (PMC3150404). [Article]

Farquhar, E. R.; Emerson, J. P.; Koehntop, K. D.; Reynolds, M. F.; Trmcic, M.; Que, L., Jr., In Vivo Self-hydroxylation of an Iron–Substituted Manganese-Dependent Extradiol Cleaving Catechol Dioxygenase. J. Biol. Inorg. Chem. 2011, 16, 589-597 (PMC3177297). [Article]

Feng, Y.; England, J.; Que, L., Jr., Iron-Catalyzed Olefin Epoxidation and cis-Dihydroxylation by Tetraalkylcyclam Complexes: the Importance of cis-Labile Sites. ACS Catal. 2011, 1, 1035–1042 (10.1021/cs200292h). [Article]

Fielding, A. J.; Kovaleva, E. G.; Farquhar, E. R.; Lipscomb, J. D.; Que, L., Jr., A Hyperactive Cobalt-Substituted Extradiol-Cleaving Catechol Dioxygenase. J. Biol. Inorg. Chem. 2011, 16, 341-355 (10.1007/s00775-014-1122-9; PMC3192431). [Article]

Hirao, H.; Li, F.; Que, L., Jr.; Morokuma, K. Theoretical Study of the Mechanism of Oxoiron(IV) Formation from H2O2 and a Nonheme Iron(II) Complex: O–O Cleavage Involving Proton-Coupled Electron Transfer. Inorg. Chem. 2011, 50, 6637-6648. (10.1021/ic200522r; PMC3136038). [Article]

Li, F.; Meier, K. K.; Cranswick, M. A.; Chakrabarti, M.; Van Heuvelen, K. M.; Münck, E.; Que, L., Jr., Characterization of a High-Spin Nonheme FeIII–OOH Intermediate and Its Quantitative Conversion to an FeIV=O Complex. J. Am. Chem. Soc. 2011, 133, 7256-7259 (10.1021/ja111742z; PMC3097042). [Article]

McDonald, A. R.; Que, L., Jr., Iron–Oxo Complexes: Elusive Iron(V) Species Identified. Nature Chem. 2011, 3, 761-762 (10.1038/nchem.1153). [Article]

Paria, S.; Que, L., Jr.; Paine, T. K., Oxidative Decarboxylation of Benzilic Acid by a Biomimetic Iron(II) Complex: Evidence for an Iron(IV)–Oxo–Hydroxo Oxidant from O2. Angew. Chem. Int. Ed. 2011, 50, 11129-11132 (10.1002/anie.201103971). [Article]

Vu, V.; Makris, T.; Lipscomb, J. D.; Que, L., Jr., Active Site Structure of a β-Hydroxylase in Antibiotic Biosynthesis. J. Am. Chem. Soc. 2011, 133, 6938-6941 (10.1021/ja201822v; PMC3096070). [Article]

Wong, S. D.; Bell, C. B., III; Liu, L. V.; Kwak, Y.; England, J.; Zhao, J.; Que, L., Jr.; Solomon, E. I., Nuclear Resonance Vibrational Spectroscopy on the FeIV=O S = 2 Nonheme Site in TMG3tren: Experimentally Calibrated Insights into Reactivity. Angew. Chem. Int. Ed. 2011, 50, 3215 –3218 (10.1002/anie.201007692; PMC3085250). [Article]

Xue, G.; Pokutsa, A.; Que, L., Jr., Substrate-Triggered Activation of a Synthetic [Fe2(μ-O)2] Diamond Core for C–H Bond Cleavage. J. Am. Chem. Soc. 2011, 133, 16657–16667 (10.1021/ja207131g; PMC3192255). [Article]

2010

Das, P.; Que, L., Jr., Iron Catalyzed Competitive Olefin Oxidation and ipso-Hydroxylation of Benzoic Acids: Further Evidence for an FeV?O Oxidant. Inorg. Chem. 2010, 49, 9479-9485 (DOI: 10.1021/ic101144s). [Article]

De Hont, R. F.; Xue, G.; Hendrich, M. P.; Que, L., Jr.; Bominaar, E. L.; Münck, E., Mössbauer, Electron Paramagnetic Resonance, and Density Functional Theory Studies of Synthetic S = 1/2 FeIII−O−FeIV?O Complexes. Superexchange-Mediated Spin Transition at the FeIV?O Site. Inorg. Chem. 2010, 49, 8310-8322 (DOI: 10.1021/ic100870v; PMCID: PMC2957120). [Article]

England, J.; Guo, Y.; Farquhar, E. R.; Young, V. G., Jr.; Münck, E.; Que, L., Jr., The Crystal Structure of a High-Spin Oxoiron(IV) Complex and Characterization of Its Self-Decay Pathway. J. Am. Chem. Soc. 2010, 132, 8635-8644 (DOI: 10.1021/ja100366c; PMC2903234).[Article]

Garcia-Bosch, I.; Company, A.; Frisch, J. R.; Torrent-Sucarrat, M.; Cardellach, M.; Gamba, I.; Güell, M.; Casella, L.; Que, L., Jr.; Ribas, X.; Luis, J. M.; Costas, M., O2 Activation and Selective Phenolate ortho Hydroxylation by an Unsymmetric Dicopper µ-n1:n1-Peroxido Complex. Angew. Chem. Int. Ed. 2010, 49, 2406-2409 (DOI: 10.1002/anie.200906749).[Article]

Janardanan, D.; Wang, Y.; Schyman, P.; Que, L., Jr.; Shaik, S., The Fundamental Role of Exchange-Enhanced Reactivity in C–H Activation by S=2 Oxo Iron(IV) Complexes. Angew. Chem. Int. Ed. 2010, 49, 3342-3346 (DOI: 10.1002/anie.201000004; PMC20358569).[Article]

Li, F., England, J., and Que, L., Jr., Near-Stoichiometric Conversion of H2O2 to FeIV=O at a Nonheme Iron(II) Center. Insights into the O-O Bond Cleavage Step. J. Am. Chem. Soc. 2010, 132, 2134-2135 (DOI: 10.1021/ja9101908; PMC2823852).[Article]

McDonald, A. R.; Bukowski, M. R.; Farquhar, E. R.; Jackson, T. A.; Koehntop, K. D.; Seo, M. S.; Hont, R. F. D.; Stubna, A.; Halfen, J. A.; Münck, E.; Nam, W.; Que, L., Jr., Sulfur versus Iron Oxidation in an Iron−Thiolate Model Complex. J. Am. Chem. Soc. 2010, 132, 17118-17129 (DOI: 10.1021/ja1045428; PMCID: PMC21070030). [Article]

Mukherjee, A.; Cranswick, M. A.; Chakrabarti, M.; Paine, T. K.; Fujisawa, K.; Münck, E.; Que, L., Jr., Oxygen Activation at Mononuclear Nonheme Iron Centers: A Superoxo Perspective. Inorg. Chem. 2010, 49, 3618-3628 (DOI: 10.1021/ic901891n; PMC20380464).[Article]

Oldenburg, P. D.; Feng, Y.; Pryjomska-Ray, I.; Ness, D.; Que, L., Jr., Olefin cis-Dihydroxylation with Bio-Inspired Iron Catalysts. Evidence for an FeII/FeIV Catalytic Cycle. J. Am. Chem. Soc. 2010, 132, 17713-17723 (DOI: 10.1021/ja1021014). [Article]

Paine, T. K.; Paria, S.; Que, L., Jr., Oxidative Decarboxylation of &alpha-Hydroxy Acids by a Functional Model of the Nonheme Iron Oxygenase, CloR. Chem. Commun. 2010, 1830-1832 (DOI: 10.1039/B925389K; PMC20198223).[Article]

Torres Martin de Rosales, R.; Faiella, M.; Farquhar, E.; Que, L., Jr.; Andreozzi, C.; Pavone, V.; Maglio, O.; Nastri, F.; Lombardi, A., Spectroscopic and Metal-binding Properties of DF3: An Artificial Protein Able to Accommodate Different Metal Ions. J. Biol. Inorg. Chem. 2010, 15, 717-728 (DOI: 10.1007/s00775-010-0639-9; PMC2915772).[Article]

Wang, D.; Zhang, M.; Bühlmann, P.; Que, L., Jr., Redox Potential and C–H Bond Cleaving Properties of a Nonheme FeIV=O Complex in Aqueous Solution. J. Am. Chem. Soc. 2010, 132, 7638-7644 (DOI: 10.1021/ja909923w; PMC20476758).[Article]

Xue, G.; De Hont, R.; Münck, E.; Que, L., Jr., Million-fold Activation of the [Fe2(µ-O)2] Diamond Core for C–H Bond Cleavage. Nature Chem. 2010, 2, 400-405 (DOI: 10.1038/nchem.586; PMC2859466).[Article]

2009

Company, A.; Feng, Y.; Güell, M.; Ribas, X.; Luis, J. M.; Que, L., Jr.; Costas, M., "Olefin-Dependent Discrimination between Two Non-heme HO-FeV=O Tautomeric Species in Catalytic H2O2 Epoxidations," Chem. Eur. J. 2009, 15, 3356-3362 (DOI:10.1002/chem.200802597). (designated as VIP by journal) [Article]

England, J.; Martinho, M.; Farquhar, E. R.; Frisch, J. R.; Bominaar, E. L.; Münck, E.; Que, L., Jr., "A Synthetic High-Spin Oxoiron(IV) Complex: Generation, Spectroscopic Characterization, and Reactivity," Angew. Chem. Int. Ed. 2009, 48, 3622-3626 (DOI: 10.1002/anie.200900863; PMC2719303). (designated as VIP by journal) [Article]

Feng, Y.; Ke, C.-y.; Xue, G.; Que, L., Jr., "Bio-inspired Arene cis-Dihydroxylation by a Non-Heme Iron Catalyst Modeling the Action of Naphthalene Dioxygenase," Chem. Commun. 2009, 50-56 (DOI: 10.1039/b817222f). [Article]

Fielder, A. T.; Que, L., Jr., "Reactivities of Fe(IV) Complexes with Oxo, Hydroxo, and Alkylperoxo Ligands: An Experimental and Computational Study," Inorg. Chem. 2009, 48, 11038–11047 (DOI: 10.1021/ic901391y; PMC2789986). [Article]

Frisch, J. R.; Vu, V. V.; Martinho, M.; Münck, E.; Que, L., Jr., "Characterization of Two Distinct Adducts in the Reaction of a Non-heme Diiron(II) Complex with O2," Inorg. Chem. 2009, 48, 8325-8336 (DOI: 10.1021/ic900961k; PMC2846601). [Article]

Johansson, A. J.; Noack, H.; Siegbahn, P. E. M.; Xue, G.; Que, L., Jr., "Observed Enhancement of the Reactivity of a Biomimetic Diiron Complex by the Addition of Water - Mechanistic Insights from Theoretical Modeling," Dalton Trans. 2009, 6741-6750 (DOI: 10.1039/b907263b; PMC2846601). [Article]

Klinker, E. J.; Shaik, S.; Hajime, H.; Que, L., Jr., "Two-State Reactivity Model Explains Unusual Kinetic Isotope Effect Patterns in C-H Bond Cleavage by Non-heme OxoironIV Complexes," Angew. Chem. Int. Ed. 2009, 48, 1291-1295 (DOI: 10.1002/anie.200804029; PMC2832581). [Article]

Makhlynets, O. V.; Das, P.; Taktak, S.; Flook, M.; Mas-Ballesté, R.; Rybak-Akimova, E. V.; Que, L., Jr., "Iron-promoted Ortho- and/or Ipso-hydroxylation of Benzoic Acids with H2O2," Chem. Eur. J. 2009, 15, 47,13171-80 (DOI: 10.1002/chem.200901296). [Article]

Martinho, M.; Xue, G.; Fiedler, A.T.; Que, L., Jr. ; Bominaar, E.; Münck, E., "Mössbauer and DFT Study of the Ferromagnetically Coupled Diiron(IV) Precursor to a Complex with an FeIV2O2 Diamond Core," J. Am. Chem. Soc. 2009, 131, 5823-5830 (DOI: 10.1021/ja8098917; PMC2675788). [Article]

Mukherjee, A.; Martinho, M.; Bominaar, E. L.; Münck, E.; Que, L., Jr., "Shape-Selective Interception by Hydrocarbons of the O2-Derived Oxidant of a Biomimetic Non-heme Iron Complex," Angew. Chem. Int. Ed. 2009, 48, 1780-1783 (DOI:10.1002/anie.200805342; PMC2719302). [Article]

Vu, V. V.; Emerson, J. P.; Martinho, M.; Kim, Y. S.; Münck, E.; Park, M. H.; Que, L., Jr., "Human Deoxyhypusine Hydroxylase, an Enzyme Involved in Regulating Cell Growth, Activates O2 with a Non-heme Diiron Center," Proc. Natl. Acad. Sci. USA 2009, 106, 14814-14819 (DOI: 10.1073/pnas.0904553106; PMC2736468). [Article]

Wang, D.; Farquhar, E. R.; Stubna, A.; Münck, E.; Que, L., Jr., "A Diiron(IV) Complex that Cleaves Strong C-H and O-H Bonds." Nature Chem. 2009, 1, 145-150 (DOI: 10.1038/nchem.162; PMC2744316). (highlighted in Nature, April 3, 2009 issue and C&ENews, April 6, 2009 issue) [Article]

2008

Bell, C. B., III; Wong, S. D.; Xiao, Y.; Klinker, E. J.; Tenderholt, A. L.; Smith, M. C.; Rohde, J.-U.; Que, L., Jr.; Cramer, S. P.; Solomon, E. I., "A Combined NRVS and DFT Study of FeIV=O Model Complexes: a Diagnostic Method for the Elucidation of Non-heme Iron Enzyme Intermediates," Angew. Chem. Int. Ed. 2008, 47, 47, 9071-9074 (DOI: 10.1002/anie.200803740; PMC2662738). [Article]

Chanda, A.; Shan, X.; Chakrabarti, M.; Ellis, W. C.; Popescu, D. L.; Tiago de Oliveira, F.; Wang, D.; Que, L., Jr.; Collins, T. J.; Münck, E.; Bominaar, E. L., "(TAML)FeIV=O Complex in Aqueous Solution: Synthesis and Spectroscopic and Computational Characterization," Inorg. Chem. 2008, 47, 3669-3678 (DOI: 10.1021/ic7022902). [Article]

Company, A.; Palavicini, S.; Garcia-Bosch, I.; Mas-Ballesté, R.; Que, L., Jr.; Rybak-Akimova, E. V.; Casella, L.; Ribas, X.; Costas, M., "Tyrosinase-Like Reactivity in a CuIII2(µ-O)2 Species," Chem. Eur. J. 2008, 14, 3535-3538 (DOI: 10.1002/chem.200800229). [Communication]

Emerson, J. P.; Kovaleva, E. G.; Farquhar, E. R.; Lipscomb, J. D.; Que, L., Jr., "Swapping Metals in Fe- and Mn-dependent Dioxygenases: Evidence for Oxygen Activation without a Change in Metal Redox State," Proc. Natl. Acad. Sci. USA 2008, 105, 21, 7347-7352 (DOI: 10.1073/pnas.0711179105; PMC2396700). [Article]

Fiedler, A. T.; Shan, X.; Mehn, M. P.; Kaizer, J.; Torelli, S.; Frisch, J. R.; Kodera, M.; Que, L., Jr., "Spectroscopic and Computational Studies of (&mu-Oxo)(µ-1,2-Peroxo)diironIII Complexes of Relevance to Non-heme Diiron Oxygenase Intermediates," J. Phys. Chem. A 2008, 112 (50), 13037–13044 (DOI:10.1021/jp8038225; PMC2736334). [Article]

Friese, S. J.; Kucera, B. E.; Young, V. G., Jr.; Que, L., Jr.; Tolman, W. B., "IronII Complexes of Sterically Bulky α-Ketocarboxylates: Structural Models for α-Ketoacid-Dependent Nonheme Iron Halogenases," Inorg. Chem. 2008, 47, 1324-1331 (DOI: 10.1021/ic701823y). [Article]

Gunderson, W. A.; Zatsman, A. I.; Emerson, J. P.; Farquhar, E. R.; Que, L., Jr.; Lipscomb, J. D.; Hendrich, M. P., "EPR Detection of Intermediates in the Enzymatic Cycle of an Extradiol Dioxygenase," J. Am. Chem. Soc. 2008, 130, 130 (44), 14465­14467 (DOI: 10.1021/ja8052255; PMC2806810). [Article].

Hirao, H.; Que, L., Jr.; Nam, W.; Shaik, S., "A Two-State Reactivity Rationale for Counterintuitive Axial Ligand Effects on the C-H Activation Reactivity of Nonheme FeIV=O Oxidants," Chem. Eur. J. 2008, 14, 1740-1756 (DOI: 10.1002/chem.200701739). [Article]

Jackson, T. A.; Rohde, J.-U.; Seo, M. S.; Sastri, C. V.; DeHont, R.; Stubna, A.; Ohta, T.; Kitagawa, T.; Münck, E.; Nam, W.; Que, L., Jr., "Axial Ligand Effects on the Geometric and Electronic Structures of Non-heme OxoironIV Complexes," J. Am. Chem. Soc. 2008, 130, 12394–12407 (DOI: 10.1021/ja8022576; PMC2574688). [Article]

Krzystek, J.; England, J.; Ray, K.; Ozarowski, A.; Smirnov, D.; Que, L., Jr.; Telser, J., "Determination by High-Frequency and -Field EPR of Zero-Field Splitting in IronIV Oxo Complexes: Implications for Intermediates in Non-heme Iron Enzymes," Inorg. Chem. 2008, 47, 3483-3485 (DOI: 10.1021/ic800411c). [Article]

Mas-Ballesté, R.; Fujita, M.; Que, L., Jr., "High-valent Iron-mediated cis-Hydroxyacetoxylation of Olefins," Dalton Trans. 2008, 1828-1830 (DOI: 10.1039/B802587H). [Article]

Oldenburg, P., D.; Mas-Ballesté, R.; Que, L., Jr., "Bio-Inspired Iron-Catalyzed Olefin Oxidations: Epoxidation Versus cis-Dihydroxylation in Mechanisms in Homogeneous and Heterogeneous Epoxidation Catalysis," in Mechanisms in Homogeneous and Heterogeneous Epoxidation Catalysis, Oyama, S. T., Ed., pp. 452-469. Elsevier: Amsterdam, 2008.

Que, L., Jr.; Tolman, W. B., "Biologically Inspired Oxidation Catalysis," Nature 2008, 455, 333-340 (DOI: 10.1038/nature07371). [Article]

Ray, K.; England, J.; Fiedler, A. T.; Martinho, M.; Münck, E.; Que, L., Jr., "An Inverted and More Oxidizing Isomer of [FeIV(O)(tmc)(NCCH3)]2+," Angew. Chem. Int. Ed. 2008, 47, 8068-8071 (DOI: 10.1002/anie.200802219; PMC2656284). [Article]

Ray, K.; Lee, S. M.; Que, L., Jr., "Iron-oxidation-state-dependent O-O Bond Cleavage of Meta-chloroperbenzoic Acid to Form an IronIV-oxo Complex," Inorg. Chim. Acta 2008, 361, 1066-1069 (DOI: 10.1002/anie.200802219; PMC2656284). [Article]

Shan, X.; Que, L., Jr., "Unexpected Kinetic Complexity in the Formation of a Non-heme OxoironIV Complex," Chem. Commun. 2008, 2209-2011 (DOI: 10.1039/B716036D). [Article]

Suzuki, K.; Oldenburg, P. D.; Que, L., Jr., "Iron-Catalyzed Asymmetric Olefin cis-Dihydroxylation with 97% Enantiomeric Excess," Angew. Chem. Int. Ed. 2008, 47, 1887-1889 (DOI: 10.1002/anie.200705061). [Article]

Thibon, A.; England, J.; Martinho, M.; Young, V. G., Jr.; Frisch, J. R.; Guillot, R.; Girerd, J.-J.; Münck, E.; Que, L., Jr.; Banse, F., "Proton- and Reductant-Assisted Dioxygen Activation by a Nonheme IronII Complex to Form an OxoironIV Intermediate," Angew. Chem. Int. Ed. 2008, 47, 7064-7067 (DOI: 10.1002/anie.200801832; PMC2652675). [Communication]

Xue, G.; Fiedler, A. T.; Martinho, M.; Münck, E.; Que, L., Jr., "Insights into the P-to-Q Conversion in the Catalytic Cycle of Methane Monooxygenase from a Synthetic Model System," Proc. Natl. Acad. Sci. USA 2008, 105, 20615-20620 (DOI: 10.1073/pnas.0808512105). [Article]

Zhou, Y.; Shan, X.; Mas-Ballesté, R.; Bukowski, M. R.; Stubna, A.; Chakrabarti, M.; Slominski, L.; Halfen, J. A.; Münck, E.; Que, L., Jr., "Contrasting cis and trans Effects on the Reactivity of Non-heme OxoironIV Complexes,"Angew. Chem. Int. Ed. 2008, 47, 1896-1899 (DOI: 10.1002/anie.200704228).
[Article]

2007

Company, A.; Gomez, L.; Guell, M.; Ribas, X.; Luis, J. M.; Que, L., Jr.; Costas, M., "Alkane Hydroxylation by a Non-heme Iron Catalyst that Challenges the Heme Paradigm for Oxygenase Action," J. Am. Chem. Soc. 2007, 129, 15766-15767. [Article]

Company, A.; Gomez, L.; Mas-Balleste, R.; Korendovych, I. V.; Ribas, X.; Poater, A.; Parella, T.; Fontrodona, X.; Benet-Buchholz, J.; Sola, M.; Que, L., Jr.; Rybak-Akimova, E. V.; Costas, M., "Fast O2 Binding at Dicopper Complexes Containing Schiff-Base Dinucleating Ligands," Inorg. Chem. 2007, 46, 4997-5012. [Article]

de Oliveira, F.T.; Chanda, A.; Banerjee, D.; Shan, X.;Mondal,S.; Que, L. Jr.; Bominaar, E. L.; Münck, E.; Collins, T. J., "Chemical and Spectroscopic Evidence for an FeV-Oxo Complex," Science 2007, 315, 835-838. [Article]

Decker, A.; Rohde, J.-U.; Klinker, E. J.; Wong, S. D.; Que, L., Jr.; Solomon, E. I., "Spectroscopic and Quantum Chemical Studies on Low-Spin FeIV=O Complexes: Fe-O Bonding and Its Contributions to Reactivity," J. Am. Chem. Soc. 2007, 129, 15983-15996. [Article]

Emerson, J. P.; Farquhar, E. R.; Que, L., Jr., "Structural 'Snapshots' along Reaction Pathways of Non-heme Iron Enzymes," Angew. Chem. Int. Ed. 2007, 46, 8553-8556. [Article]

Jensen, M. P.; Mairata i Payeras, A.; Fiedler, A. T.; Costas, M.; Kaizer, J.; Stubna, A.; Münck, E.; Que, L., Jr., "Kinetic Analysis of the Conversion of Nonheme (Alkylperoxo)ironIII Species to IronIV Complexes," Inorg. Chem. 2007, 46, 2398-2408. [Article]

Klotz, K. L.; Slominski, L. M.; Hull, A. V.; Gottsacker, V. M.; Mas-Ballesté, R.; Que, L., Jr.; Halfen, J. A., "Non-heme IronII Complexes are Efficient Olefin Aziridination Catalysts," Chem. Commun. 2007, 2063-2065. [Article]

Mas-Ballesté, R.; Que, L., Jr., "Iron-Catalyzed Olefin Epoxidation in the Presence of Acetic Acid: Insights into the Nature of the Metal-Based Oxidant," J. Am. Chem. Soc. 2007, 129, 15964-15972. [Article]

Paine, T. K.; England, J.; Que, L., Jr., "Iron-Catalyzed C2-C3 Bond Cleavage of Phenylpyruvate with O2: Insight into Aliphatic C-C Bond-Cleaving Dioxygenases," Chem. Eur. J. 2007, 13, 6073 -6081. [Article]

Que, L., Jr., "The Road to Non-heme Oxoferryls and Beyond," Acc. Chem. Res. 2007, 40, 493-500.[ Article]

Rohde, J.-U.; Betley, T. A.; Jackson, T. A.; Saouma, C. T.; Peters, J. C.; Que, L., Jr., "XAS Characterization of a NitridoironIV Complex with a Very Short Fe-N Bond," Inorg. Chem. 2007, 46,5720-5726. [Article]

Sastri, C. V.; Lee, J.; Oh, K.; Lee, Y. J.; Lee, J.; Jackson, T. A.; Ray, K.; Hirao, H.; Shin, W.; Halfen, J. A.; Kim, J.; Que, L., Jr.; Shaik, S.; Nam, W., "Axial Ligand Tuning of a Non-heme IronIV-oxo Unit for Hydrogen Atom Abstraction," Proc. Natl. Acad. Sci. USA 2007, 104, 19181-19186. [Article]

Shan, X.; Rohde, J.-U.; Koehntop, K. D.; Zhou, Y.; Bukowski, M. R.; Costas, M.; Fujisawa, K.; Que, L., Jr., "X-ray Absorption Spectroscopic Studies of High-Spin Non-heme (Alkylperoxo)ironIII Intermediates," Inorg. Chem. 2007, 46 (20), 8410 -8417.[Article]

Smith, A. L.; Day, C. S.; Que, L., Jr.; Zhou, Y.; Bierbach, U., "Unexpected Assembly of a Novel Triply Bridged DiironII Core by a Bidentate Schiff Base Ligand," Inorg. Chim. Acta 2007, 360, 2824-2828. [Article]

Xue, G.; Wang, D.; De Hont, R.; Fiedler, A. T.; Shan, X.; Münck, E.; Que, L., Jr., "A Synthetic Precedent for the [FeIV2(µ-O)2] Diamond Core Proposed for Methane Monooxygenase Intermediate Q," Proc. Natl. Acad. Sci. USA 2007, 104, 20713-20718. [Article]

2006

Bautz, J.; Bukowski, M. R.; Kerscher, M.; Stubna, A.; Comba, P.; Lienke, A.; Münck, E,; Que, L., Jr., "Formation of an Aqueous OxoironIV Complex at pH 2-6 from a Non-Heme IronII Complex and H2O2," Angew. Chem. Int. Ed. 2006, 45, 5681-5684. [Article]

Bautz, J.; Comba, P.; Que, L., Jr., "Spin-Crossover in an IronIII-BispidineAlkylperoxide System," Inorg. Chem. 2006, 45, 7077-7082. [Article]

Bukowski, M. R.; Comba, P.; Lienke, A.; Limberg, C.; Lopez de Laorden, C.; Mas-Ballesté, R.; Merz, M.; Que, L., Jr., "Catalytic Epoxidation and 1.2-Dihydroxylation of Olefins with Bispidine-IronII/H2O2 Systems," Angew. Chem. Int. Ed. 2006, 45, 3446-3449. [Article]

Collins, M. J.; Ray, K.; Que, L., Jr., "Electrochemical Generation of a Nonheme OxoironIV Complex," Inorg. Chem. (Communication), 2006, 45, 8009-8011. [Article]

Friese, S. J.; Kucera, B. E.; Que, L., Jr.; Tolman, W. B., "Self-Assembly of the 2-His-1-carboxylate Facial Triad in Mononuclear IronII and ZincII Models of Metalloenzyme Active Sites," Inorg. Chem. (Communication), 45, 8003-8005. [Article]

Hirao, H.; Kumar, D.; Que, L., Jr.; Shaik, S., "Two-State Reactivity in Alkane Hydroxylation by Non-Heme Iron-Oxo Complexes," J. Am. Chem. Soc. 2006, 128, 8590-8606. [Article]

Klein, D. P.; Young, V. G., Jr.; Tolman, W. B.; Que, L., Jr., "Mononitrosyl Iron Complexes Supported by Sterically Hindered Carboxylate Ligands," Inorg. Chem. (Communication), 2006, 45, 8006-8008. [Article]

Koehntop, K. D.; Marimanikkuppam, S.; Ryle, M. J.; Hausinger, R. P.; Que, L., Jr., "Self-hydroxylation of Taurine/&alpha-ketoglutarate Dioxygenase: Evidence for More than One Oxygen Activation Mechanism," J. Biol. Inorg. Chem. 2006, 11:1, 63-72. [Article]

Mas-Ballesté, R.; Costas, M., van den Berg, T., Que, L., Jr., "Ligand Topology Effects on Olefin Oxidations by Bio-Inspired [FeII(N2Py2)] Catalysts," Chem. Eur. J. 2006, 12, 7489-7500.[Article]

Mas-Ballesté, R.; Fujita, M.; Hemmila, C., Que, L., Jr., "Bio-Inspired Iron-Catalyzed Olefin Oxidation: Additive Effects on the cis-Diol/epoxide Ratio," J. Mol. Catal. A: Chem. 2006, 251, 49-53. [Article]

Mas-Ballesté, R.;Que, L.,Jr., "CHEMISTRY:Targeting Specific C-H Bonds for Oxidation,Science 30, June 2006:
312:5782, 1885-1886. [Article]

Mehn, M. P.; Brown, S. D.; Jenkins, D. M.; Peters, J. C.; Que, L., Jr., "Vibrational Spectroscopy and Analysis of Pseudo-Tetrahedral Complexes with Metal Imido Bonds," Inorg. Chem. 2006, 45, 7417-7427. [Article]

Mehn, M. P.; Brown, S. D.; Paine, T. K.; Brennessel, W. W.; Cramer, C. J.; Peters, J. C.; Que, L., Jr., "High-spin and Low-spin IronII Complexes with Facially-Coordinated Borohydride Ligands," Dalton Trans. 2006, 1347-1351. [Article]

Oldenburg, P. D.; Ke, C.-Y.; Tipton, A. A.; Shteinman, A. A.; Que, L., Jr., "A Structural and Functional Model for Dioxygenases with a 2-His-1-carboxylate Triad," Angew. Chem. Int. Ed. 2006, 45, 7975-7978.[Article]

Oldenburg, P.; Que, L., Jr., "Bio-Inspired Non-Heme Iron Catalysts for Olefin Oxidation," Catal. Today, 2006, 117, 15-21.[Article]

Paine, T. K.; Costas, M.; Kaizer, J.; Que, L., Jr., "OxoironIV Complexes of the Tris(2-pyridylmethyl)amine Ligand Family: Effect of Pyridine &alpha-substituents," J. Biol. Inorg. Chem. 2006, 11:3, 272-276.[Article]

Rohde, J.-U.; Stubna, A.; Bominaar, . L.; Münck, E.; Nam, W.; Que, L., Jr., "Nonheme OxoironIV Complexes of Tris(2-pyridylmethyl)amine with cis-Momoanionic Ligands," Inorg. Chem. 2006, 45, 6435-6445. [Article]

Shan, X.; Que, L., Jr., "High-valent Nonheme Iron-Oxo Species in Biomimetic Oxidations," J. Inorg. Biochem. 2006, 100, 421-433. [Article]


2005

Bassan, A.; Blomberg, M. R. A.; Siegbahn, P. E. M.; Que, L., Jr., "A Density Functional Study on a Biomimetic Non-Heme Iron Catalyst: Insights into Alkane Hydroxylation by a Formally HO-FeV=O Oxidant," Chem. Eur. J. 2005, 11, 692-705.[Article]

Bassan, A.; Blomberg, M. R. A.; Siegbahn, P. E. M.; Que, L., Jr., "Two Faces of a Biomimetic Non-Heme HO-FeV=O Oxidant: Olefin Epoxidation versus cis-Dihydroxylation," Angew. Chem. Int. Ed. 2005, 44, 2939-2941. [Article]

Bukowski, M. R.; Halfen, H. L.; van den Berg, T. A.; Halfen, J. A.; Que, L., Jr., "Spin-State Rationale for the Peroxo-Stabilizing Role of the Thiolate Ligand in Superoxide Reductase," Angew. Chem. Int. Ed. 2005, 44, 584-587.[Article]

Bukowski, M. R.; Koehntop, K. D.; Stubna, A.; Bominaar, E. L.; Halfen, J. A.; Münck, E.; Nam, W.; Que, L., Jr., "A Thiolate-Ligated Nonheme OxoironIV Complex Relevant to Cytochrome P450," Science 2005, 310, 1000-1002. [Article]

Earhart, C. A.; Vetting, M. W.; Gosua, R.; Michaud-Soret, I.; Que, L., Jr.; Ohlendorf, D. H., "Structure of Catechol 1,2-dioxygenase from Pseudomonas arvilla," Biochem. Biophys. Res. Commun. 2005, 338, 198-205. [Article]

Emerson, J. P.; Wagner, M. L.; Reynolds, M. F.; Que, L., Jr; Sadowsky, M. J.; Wackett, L. P., "The Role of Histidine 200 in MndD, the MnII-dependent 3,4-dihydroxyphenylacetate 2,3-dioxygenase from Arthrobacter globiformis CM-2, a Site-directed Mutagenesis Study," J Biol. Inorg. Chem. 2005, 10, 751-760. [Article]

Farquhar, E. R.; Koehntop, K. D.; Emerson, J. P.; Que, L., Jr., "Post-translational Self-hydroxylation: A Probe for Oxygen Activation Mechanisms in Non-heme Iron Enzymes," Biochem. Biophys. Res. Commun. 2005, 338, 230-239. [Article]

Jensen, M. P., Costas, M., Ho, R. Y. N., Kaizer, J., Mairata i Payeras, A., Münck, E., Que, L., Jr., Rohde, J.-U., and Stubna, A., "High-Valent Nonheme Iron. Two Distinct IronIV Species Derived from a Common IronII Precursor," J. Am. Chem. Soc. 2005, 127, asap.[Publisher's Site]

Klinker, E. J.; Kaizer, J.; Brennessel, W. W.; Woodrum, N. L.; Cramer, C. J.; Que. L., J., "Structures of Nonheme OxoironIV Complexes from X-ray Crystallography, NMR Spectroscopy, and DFT Calculations," Angew. Chem. Int. Ed. 2005, 44, 3690-3694.[Article]

Koehntop, K. D.; Emerson, J. P.; Que, L., Jr., "The 2-His-1-carboxylate Facial Triad: A Versatile Platform for Dioxygen Activation by Mononuclear Nonheme IronII Enzymes," J. Biol. Inorg. Chem. 2005, 10, 87-93.[Article]

Kryatov, S. V.; Taktak, S.; Korendovych, I. V.; Rybak-Akimova, E. V.; Kaizer, J.; Torelli, S.; Shan, X.; Mandal, S.; MacMurdo, V.; Mairata i Payeras, A.; Que, L., Jr., "Dioxygen Binding to Complexes with FeII2(μ-OH)2 Cores: Steric Control of Activation Barriers and O2-Adduct Formation," Inorg. Chem. 2005, 44, 85-99.[Article]

Kumar,D.; Hirao, H.; Que, L., Jr.; Shaik, S., "Theoretical Investigation of C-H Hydroxylation by (N4Py)FeIV=O2+: An Oxidant More Powerful than P450?," J. Am. Chem. Soc. 2005, 127, 8026-8027.[Article]

Oh, N. Y.; Seo, M. S.; Lim, M. H.; Consugar, M. B.; Park, M. J.; Rohde, J.-U.; Han, J.; Kim, K. M.; Kim, J.; Que, L., Jr.; Nam, W., "Self-hydroxylation of Perbenzoic Acids at a Nonheme IronII Center," Chem. Commun. 2005, 5644-5646. [Article]

Oldenburg, P. D.; Shteinman, A. A.; Que, L., Jr., "Iron-Catalyzed Olefin cis-Dihydroxylation Using a Bio-Inspired N,N,O-Ligand," J. Am. Chem. Soc. 2005, 127, 15672-15673. [Article]

Pestovsky, O.; Stoian, S.; Bominaar, E. L.; Shan, X.; Münck, E.; Que, L., Jr.; Bakac, A., "Aqueous FeIV=O: Spectroscopic Identification and Oxo Group Exchange," Angew. Chem. Int. Ed. 2005, 44, 6871-6874.[Article]

Quiñonero, D.; Morokuma, K.; Musaev, D. G.; Mas-Balleste, R.; Que, L., Jr., "Metal-Peroxo versus Metal-Oxo Oxidants in Non-Heme Iron-Catalyzed Olefin Oxidations: Computational and Experimental Studies on the Effect of Water," J. Am. Chem. Soc. 2005, 127, 6548-6549.[Article]

Rohde, J.-U.; Que, L., Jr., "Axial Coordination of Carboxylate Activates the Non-heme FeIV=O Unit," Angew. Chem. Int. Ed. 2005, 44, 2255-2258.[Publisher's Site]

Sastri, C. V.; Park, M. J.; Ohta, T.; Jackson, T. A.; Stubna, A.; Seo, M. S.; Lee, J.; Kim, J.; Kitagawa, T.; Münck, E.; Que, L., Jr.; Nam, W., "Axial Ligand Substituted Nonheme Fe=O Complexes: Observation of Near UV LMCT Bands and Fe=O Raman Vibrations," J. Am. Chem. Soc. 2005, 127, 12494-12495. [Article]

Shan, X.; Que, L., Jr., "Intermediates in the Oxygenation of a Nonheme DiironII Complex, Including the First Evidence for a Bound Superoxo Species," Proc. Natl. Acad. Sci. USA 2005, 102, 5340-5345.[Article]

Taktak, S.; Flook, M.; Foxman, B. M.; Que, L., Jr.; Rybak-Akimova, E. V., "Ortho-Hydroxylation of Benzoic Acids with Hydrogen Peroxide at a Nonheme Iron Center," Chem. Commun. 2005, 5301–5303. [Article]

Tierney, D. L.; Rocklin, A. M.; Lipscomb, J. D.; Que, L., Jr.; Hoffman, B. M., "ENDOR Studies of the Ligation and Structure of the Non-Heme Iron Site in ACC Oxidase," J. Am. Chem. Soc. 2005, 127, 7005-7013.[Article]

 

2004

   

Bukowski, M. R.; Comba, P.; Limberg, C.; Merz, M.; Que, L., Jr.; Wistuba, T., "Bispidine Ligand Effects on Iron/Hydrogen Peroxide chemistry," Angew. Chem. Int. Ed. 2004, 43, 1283-1287.[Publisher's Site]

Bukowski, M. R.; Zhu, S.; Koehntop, K. D.; Brennessel, W. W.; Que, L., Jr., "Characterization of an FeIII-OOH Species and its Decomposition Product in a Bleomycin Model System," J. Biol. Inorg. Chem. 2004, 1, 39-48.[Publisher's Site]

Costas, M.; Mehn, M. P.; Jensen, M. P.; Que, L., Jr., "Oxygen Activation at Mononuclear Non-Heme Iron: Enzymes, Intermediates, and Models," Chem. Rev. 2004, 104, 939-986.[Publisher's Site]

Decker, A.; Rohde, J.-U.; Que, L., Jr.; Solomon, E. I., "Spectroscopic and Quantum Chemical Characterization of the Electronic Structure and Bonding in a Non-Heme FeIV=O Complex," J. Am. Chem. Soc. 2004, 126, 5378-5379. [Publisher's Site]

Fujita, M.; Que, L., Jr., "In situ Formation of Peracetic Acid in Iron-Catalyzed Epoxidations by Hydrogen Peroxide in the Presence of Acetic Acid," Adv. Synth. Catal. 2004, 346, 190-194.[Article]

Ghosh, A.; Tangen, E.; Gonzalez, E.; Que, L., Jr., "Models of high-valent intermediates of nonheme diiron alkane monooxygenases. Electronic structure of a bis(μ-oxo)diiron(IV) complex with locally low-spin metal centers," Angew. Chem. Int. Ed. 2004, 43, 834-838.[Publisher's Site]

Kaizer, J.; Klinker, E. J.; Oh, N. Y.; Rohde, J.-U.; Song, W. J.; Stubna, A.; Kim, J.; Nam, W.; Münck, E.; Que, L., Jr., "Nonheme FeIVO complexes that can oxidize the C-H bonds of cyclohexane at room temperature," J. Am. Chem. Soc. 2004, 126, 472-473.[Publisher's Site]

Koehntop, K. D.; Rohde, J.-U.; Costas, M.; Que, L., Jr., "XAS characterization of end-on and side-on peroxoiron(III) complexes of the neutral pentadentate N-donor ligand N-methyl-N,N,N-tris(2 pyridylmethyl)ethane-1,2-diamine," Dalton Trans. 2004, 3191-3198.[Article]

Kryatov, S. V.; Chavez, F. A.; Reynolds, A. M.; Rybak-Akimova, E. V.; Que, L., Jr.; Tolman, W. B. "Mechanistic Studies on the Formation and Reactivity of Dioxygen Adducts of Diiron Complexes Supported by Sterically Hindered Carboxylates," Inorg. Chem. 2004, 43, 2141-2150. [Publisher's Site]

Liu, P.; Mehn, M. P.; Yan, F.; Zhao, Z.; Que, L., Jr.; Liu, H.-w., "Oxygenase Activity in the Self-Hydroxylation of (S)-2-Hydroxypropylphosphonic Acid Epoxidase Involved in Fosfomycin Biosynthesis," J. Am. Chem. Soc. 2004, 126, 10306-10312.[Article]

Mairata i Payeras, A; Ho, R.Y. N.; Fujita, M,; Que, L. Jr. "The Reaction of [FeII(tpa)] with H2O2 in Acetonitrile and Acetone - Distinct Intermediates and Yet Similar Catalysis," Chem. Eur. J., 2004, 10, 4944-4953. [Publisher's Site]

Rocklin, A. M.; Kato, K.; Liu, H.-w.; Que, L., Jr.; Lipscomb, J. D., "Mechanistic Studies of 1-Aminocyclopropane-1-Carboxylic Acid Oxidase: Single Turnover Reactions," J. Biol. Inorg. Chem. 2004, 9, 171-182.[Publisher's Site]

Rohde, J.-U.; Torelli, S.; Shan, X.; Lim, M. H.; Klinker, E. J.; Kaizer, J.; Chen, K.; Nam, W.; Que, L., Jr., "Structural Insights into Nonheme Alkylperoxoiron(III) and Oxoiron(IV) Intermediates by X-ray Absorption Spectroscopy," J. Am. Chem. Soc. 2004, 126, 16750-16761.[Article]

Seo, M. S.; In, J.-H.; Kim, S. O.; Oh, N. Y.; Hong, J.; Kim, J.; Que, L., Jr.; Nam, W. "Direct Evidence for Oxygen-Atom Exchange between Nonheme Oxoiron(IV) Complexes and Isotopically Labeled Water," Angew. Chem. Int. Ed. 2004, 43, 2417-2420.[Publisher's Site]

Stubna, A.; Jo, D.-H.; Costas, M.; Brennessel, W. W.; Andres, H.; Bominaar, E. L.; Münck, E.; Que, L., Jr. "A Structural and Mössbauer Study of Complexes with Fe2(μ-O(H))2 Cores: Stepwise Oxidation from FeII(μ-OH)2FeII through FeII(μ-OH)2FeIIIto FeIII(μ-O)(μ-OH)FeIII" Inorg. Chem. 2004, 43, 3067-3079 [Publisher's Site]

Vetting, M. W.; Wackett, L. P.; Que, L., Jr.; Lipscomb, J. D.; Ohlendorf, D. H., "A Crystallographic Comparison of Manganese and Iron Dependent Homoprotocatechuate 2,3-Dioxygenases" J. Bacteriol. 2004, 186, 1945-1958. [Publisher's Site]

Zlateva, T.; Quaroni, L.; Que, L., Jr.; Stankovich, M. T., "Redox Studies of Subunit Interactivity in Aerobic Ribonucleotide Reductase from Escherichia coli," J. Biol. Chem. 2004, 279, 18742-18747. [Publisher's Site]

2003

Buck, B.; Mascioni, A.; Que, L., Jr.; Veglia, G. "Dealkylation of Organotin Compounds by Biological Dithiols: Toward the Chemistry of Organotin Toxicity," J. Am. Chem. Soc. 2003, 125, 13316-13317.[Publisher's Site]

Costas, M.; Cady, C. W.; Kryatov, S. V.; Ray, M.; Ryan, M. J.; Rybak-Akimova, E. V.; Que, L., Jr., "Role of Carboxylate Bridges in Modulating Nonheme Diiron(II)/O2 Reactivity," Inorg. Chem. 2003, 42, 7519-7530.[Publisher's Site]

Fujita, M.; Costas, M.; Que, L., Jr., "Iron Catalyzed Olefin cis-Dihydroxylation by H2O2: Electrophilic versus Nucleophilic Mechanisms," J. Am. Chem. Soc. 2003, 125, 9912-9913. [Publisher's Site]

Hagadorn, J. R.; Theresa I. Zahn; Que, L., Jr.; Tolman, W. B., "Dicopper(I,I) and Delocalized Mixed-Valent Dicopper(I,II) Complexes of a Sterically Hindered Carboxylate Ligand,"  Dalton Trans. 2003, 1790-1794. [Publisher's Site]

Jensen, M. P.; Lange, S. J.; Mehn, M. P.; Que, E. L.; Que, L., Jr., "Biomimetic Aryl Hydroxylation Derived from Alkyl Hydroperoxide at a Nonheme Iron Center. Evidence for an FeIV=O Oxidant" J. Am. Chem. Soc. 2003, 125, 2113-2128. [Publisher's Site]

Jensen, M. P.; Mehn, M. P.; Que, L., Jr., "Intramolecular Aromatic Amination through Iron-Mediated Nitrene TransferAngew. Chem. Int. Ed. 2003, 42, 4357-4360. [Publisher's Site]

Kaizer, J.; Costas, M.; Que, L., Jr., "A Dramatic Push Effect on the Homolysis of FeIII(OOR) Intermediates To Form Nonheme FeIV=O Complexes" Angew. Chem. Int. Ed. 2003, 42, 3671-3673.[Publisher's Site]

Lim, M. H.; Rohde, J.-U.; Stubna, A.; Bukowski, M. R.; Costas, M.; Ho, R. Y. N.; Münck, E.; Nam, W.; Que, L., Jr., "An FeIV=O Complex of a Tetradentate Tripodal Nonheme Ligand." Proc. Natl. Acad. Sci. USA 2003, 100, 3665-3670. [Publisher's Site]

Mehn, M. P.; Fujisawa, K.; Hegg, E. L.; Que, L., Jr., "Oxygen Activation by Nonheme Iron(II) Complexes: α-Keto Carboxylate versus Carboxylate,J. Am. Chem. Soc. 2003, 125, 7828-7842. [Publisher's Site]

Nam, W.; Choi, S. K.; Lim, M. H.; Rohde, J.-U.; Kim, I.; Kim, J.; Kim, C.; Que, L., Jr., "Formation of Iodosylbenzene-Iron Porphyrin Intermediates in the Reactions of Oxoiron(IV) Porphyrin p-Cation Radicals and Iodobenzene," Angew. Chem. Int. Ed., 2003, 42, 109-111. [Publisher's Site ]

Que, L., Jr.; Tolman, W. B., "Recurring Structural Motifs in Bioinorganic Chemistry," in Bio-Coordination Chemistry (Que, L., Jr.; Tolman, W. B., Eds.); Volume 8 of Comprehensive Coordination Chemistry II (McCleverty, J.; Meyer, T. J. , Eds.) Elsevier, Amsterdam, 2003; pp 1-15.[Publisher's Site]

Reynolds, M. F.; Costas, M.; Ito, M.;Jo, D.-H.; Tipton, A. A.; Whiting, A. K., and Que, L., Jr., "4-Nitrocatechol as a Probe of a Mn(II)-Dependent Extradiol-Cleaving Catechol Dioxygenase (MndD). Comparison with Relevant Fe(II) and Mn(II) Model Complexes," J. Biol. Inorg. Chem. 2003, 8, 263-272. [Publisher's Site]

Roelfes, G.; Vrajmisu, V.; Chen, K.; Ho, R. Y. N.; Rohde, J.-U.; Zondervan, C.; la Crois, R. M.; Schudde, E. P.; Lutz, M.; Spek, A. L.; Hage, R.; Feringa, B. L.; Münck, E.; Que, L., Jr., "End-on and Side-on Peroxo Derivatives of Non-Heme Iron Complexes with Pentadentate Ligands: Models for Putative Intermediates in Biological Iron/Dioxygen Chemistry,"  Inorg. Chem. 2003, 42, 2639-2653. [Publisher's Site]

Rohde, J.-U.; In, J. H.; Lim, M. H.; Brennessel, W. W.; Bukowski, M. R.; Stubna, A.; Münck, E.; Nam, W.; Que, L., Jr., "Crystallographic and Spectroscopic Evidence for a Nonheme FeIV=O Complex," Science 2003, 299, 1037-1039 [Publisher's Site]

Rohde, J.-U.; Bukowski, M. R.; Que, L., Jr., "Functional Models for Mononuclear Nonheme Iron Enzymes," Curr. Op. Chem. Biol. 2003, 7, 674-682.[Publisher's Site]

Ryle, M. J.; Koehntop, K. D.; Liu, A.; Que, L., Jr.; Hausinger, R. P., "Interconversion of two oxidized forms of taurine/a-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding,"  Proc. Natl. Acad. Sci. USA 2003,100, 3790-3795. [Publisher's Site]

Ryle, M. J.; Liu, A.; Muthukumaran, R. B.; Ho, R. Y. N.; Koehntop, K. D.; McCracken, J.; Que, L., Jr.; Hausinger, R. P., "O2- and α-Ketoglutarate-Dependent Tyrosyl Radical Formation in TauD, an a-Keto Acid-Dependent Non-Heme Iron Dioxygenase," Biochemistry 2003, 42,1854-1862. [Publisher's Site]

Skulan, A. J.; Hanson, M. A.; Hsu, H.-f.; Dong, Y.; Que, L., Jr.; Solomon, E. I., "EPR Spectroscopy of [Fe2O2(5-Et3-TPA)2]3+: Electronic Origin of the Unique Spin-Hamiltonian Parameters of the Fe2III,IVO2 Diamond Core,Inorg. Chem. 2003, 42, 6489-6496. [Publisher's Site]

Skulan, A. J.; Hanson, M. A.; Hsu, H.-f.; Que, L., Jr.; Solomon, E. I., "Spectroscopic Study of [Fe2O2(5-Et3-TPA)2]3+: Nature of the Fe2O2 Diamond Core and Its Possible Relevance to High-Valent Binuclear Non-Heme Enzyme Intermediates, J. Am. Chem . Soc. 2003, 125, 7344-7356.[Publisher's Site]


2002

Bassan, A.; Blomberg, M. R. A.; Siegbahn, P. E. M.; Que, L., Jr., "A Density Functional Study of O-O Bond Cleavage for a Biomimetic Non-Heme Iron Complex Demonstrating an FeV Intermediate," J. Am. Chem. Soc. 2002, 124, 11056-11063. [Publisher's Site]

Chavez, F. A.; Ho, R. Y. N.; Pink, M.; Young, V. G., Jr.; Kryatov, S. V.; Rybak-Akimova, E. V.; Andres, H. P.; Münck, E.; Que, L., Jr.; Tolman, W. B., "Unusual Peroxo Intermediates in the Reaction of Dioxygen with Carboxylate-Bridged Diiron(II,II) Paddlewheel Complexes," Angew. Chem. Int. Ed. 2002, 41, 149-152. [Abstract]

Chen, K.; Costas, M.; Kim, J.; Tipton, A. K.; Que, L., Jr., "Olefin cis-Dihydroxylation versus Epoxidation by Nonheme Iron Catalysts: Two Faces of an FeIII-OOH Coin," J. Am. Chem. Soc. 2002, 124, 3026-3035. [Publisher's Site]

Chen, K.; Costas, M.; Que, L., Jr., "Spin State Tuning of Non-Heme Iron-Catalyzed Hydrocarbon Oxidations: Participation of FeIII-OOH and FeV=O Intermediates," Dalton Trans. 2002, 672-679. [Publisher's Site]

Costas, M.; Que, L., Jr., "Ligand Topology Tuning of Iron-Catalyzed Hydrocarbon Oxidations," Angew. Chem. Int. Ed. 2002, 41, 2179-2181. [Publisher's Site]

DiDonato, M.; Zhang, J.; Que, L., Jr., Sarkar, B., "Zinc Binding to the N-Terminal Domain of the Wilson Disease Copper-Transporting ATPase: Implications for in vivo Metal Ion Mediated Regulation of ATPase Activity," J. Biol. Chem. 2002, 277, 13409-13414. [Publisher's Site]

Hummel, H.; Mekmouche, Y.; Duboc-Toia, C.; Ho, R. Y. N.; Que, L., Jr.; Schünemann, V.; Thomas, F.; Trautwein, A.; Lebrun, C.; Fontecave, M.; Ménage, S., "A New Diferric Peroxo Complex with an Unprecedented Spin Configuration: an S = 2 System Arising from an S = 5/2, 1/2 Pair," Angew. Chem.Int. Ed. 2002, 41, 617-620. [Abstract]

Lehnert, N.; Neese, F.; Ho, R. Y. N.; Que, L., Jr.; Solomon, E. I., "Electronic Structure and Reactivity of Low-spin Fe(III)-Hydroperoxo Complexes: Comparison to Activated Bleomycin," J. Am. Chem. Soc. 2002, 124, 10810-10822. [Publisher's Site]

Mekmouche, Y.; Hummel, H.; Ho, R. Y. N.; Que, L., Jr.; Schünemann, V.; Thomas, F.; Trautwein, A. X.; Lebrun, C.; Gorgy, K.; Leprêtre, J.-C.; Collomb, M.-N.; Deronzier, A.; Fontecave, M.; Ménage, S., "Sulfide Oxidation by Hydrogen Peroxide Catalyzed by Iron Complexes: Two Metal Centers Are Better Than One," Chem. Eur. J. 2002, 8, 1196-1204. [Publisher's Site]

Que, L., Jr.; Tolman, W. B., "Bis(μ-oxo)dimetal "Diamond" Cores in Copper and Iron Complexes Relevant to Biocatalysis," Angew. Chem.Int. Ed. 2002, 41, 1114-1137. [Publisher's Site]

Ryu, J. Y.; Kim, J.; Costas, M.; Chen, K.; Nam, W.; Que, L., Jr., "High conversion of olefins to cis-diols by non-heme iron catalysts and H2O2," Chem. Commun. 2002, 1288-1289. [Publisher's Site]

Smoukov, S. K.; Quaroni, L.; Wang, X.; Doan, P. E.; Hoffman, B. M.; Que, L., Jr., "ENDOR Evidence for a Hydroxo-Bridge Nucleophile Involved in Catalysis by a Dinuclear Hydrolase," J. Am. Chem. Soc. 2002, 124, 2595-2603. [Publisher's Site]

Tolman, W. B.; Que, L., Jr., "Sterically Hindered Benzoates: A Synthetic Strategy for Modeling Dioxygen Activation at Metalloprotein Active Sites," Dalton Trans. 2002,653-660. [Publisher's Site]

Zhu, S.; Brennessel, W. W.; Harrison, R. G.; Que., L., Jr., "Iron coordination chemistry of N-(bis(2-pyridyl)methyl)pyridine-2-carboxamide," Inorg. Chim. Acta 2002, 337, 32-38. [Publisher's Site]

Zhou, J.; Rocklin, A. M.; Lipscomb, J. D.; Que, L., Jr.; Solomon, E. I., "Spectroscopic Studies of 1-Aminocyclopropane-1-carboxylic Acid Oxidase: Molecular Mechanism and CO2 Activation in the Biosynthesis of Ethylene," J. Am. Chem. Soc. 2002, 124, 4602-4609. [Publisher's Site]


2001

Arakawa, H.; Aresta, M.; Armour, J. N.; Barteau, M. A.; Beckman, E. J.; Bell, A. T.; Bercaw, J. E.; Creutz, C.; Dinjus, E.; Eckert, J.; Fujita, E.; Gibson, D. H.; Goddard, W. A.; Goodman, D. W.; Keller, J.; Kubas, G. J.; Kung, H. H.; Lyons, J. E.; Manzer, L. E.; Marks, T. J.; Morokuma, K.; Nivholas, K. M.; Periana, R.; Que, L.; Rostrup-Nielson, J.; Sachtler, W. M. H.; Schmidt, L. D.; Sen, A.; Somorjai, G. A.; Stair, P. C.; Stults, B. R.; Tumas, W., Catalysis Research of Relevance to Carbon Management: Progress, Challenges, and Opportunities. Chem. Rev. 2001, 101, 953-996. [Publisher's Site]

Branum, M. E.; Tipton, A. K.; Zhu, S.; Que, L., Jr., Double-Strand Hydrolysis of Plasmid DNA by Dicerium Complexes J. Am. Chem. Soc. 2001, 123, 1898-1904. [Abstract]

Brennessel, W. W.; Brooks, N. R.; Mehn, M. P.; Que, L., Jr.; Young, V. G., Jr., "Hexakis(acetonitrile)iron(II) hexafluoroantimonate" Acta Cryst. 2001, E57, m545-m546.

Chavez, F. A.; Que, L., Jr.; Tolman, W. B., Metal Ion Complexation by a New, Highly Sterically Hindered, Bowl-Shaped Carboxylate Ligand. Chem. Commun. 2001, 111-112. [Publisher's Site]

Chen, K; L. Que, Jr., "Stereospecific Alkane Hydroxylation by Nonheme Iron Catalysts: Mechanisitc Evidence for an FeV=O Active Species" J. Am. Chem. Soc. 2001, 123, 6327-6337. [Abstract]

Costas, M.; Rohde, J.-U.; Stubna, A.; Ho, R. Y. N.; Quaroni, L.; Münck, E.; Que, L., Jr., "A Synthetic Model for the Putative FeIV2O2 Diamond Core of Methane Monooxygenase Intermediate Q" J. Am. Chem. Soc. 2001, 123, 12931-12932. [Communication]

Costas, M.; Tipton, A. K.; Chen, K.; Jo, D.-H.; Que, L., Jr., "Modeling Rieske Dioxygenases. The First Example of Iron-Catalyzed Asymmetric cis-Dihydroxylation of Olefins" J. Am. Chem. Soc. 2001, 123, 6722-6723 [Communication]

Halfen, J. A.; Fox, D. C.; Mehn, M. P.; Que, L., Jr., "Enhanced Reactivity of Copper Catalysts for Olefin Aziridination by Manipulation of Ancillary Ligand Denticity" Inorg. Chem. 2001, 40, 5060-5061. [Paper]

Ho, R. Y. N.; M. P. Mehn; E. L. Hegg; A. Liu; M. J. Ryle; R. P. Hausinger; and L. Que, Jr., Resonance Raman Studies of the Iron(II)-a-Keto Acid Chromophore in Model and Enzyme Complexes. J. Am. Chem. Soc. 2001, 123, 5022-5029. [Abstract]

Jo, D.-H; Y.-M. Chiou; and L. Que, Jr., Models for Extradiol Cleaving Catechol Dioxygenases: Syntheses, Structures, and Reactivities of Iron(II)-Monoanionic Catecholate Complexes Inorg. Chem.,2001, 40, 3181-3190. [Abstract]

Kim, J.; Zang, Y.; Costas, M.; Harrison, R. G.; Wilkinson, E. C.; Que, L., Jr., A Nonheme Iron(II) Complex That Models the Redox Cycle of Lipoxygenase. J. Biol. Inorg. Chem. 2001, 6, 276-284. [Abstract]

Kryatov S. V.; E. V. Rybak-Akimova; V. L. MacMurdo; and L. Que, Jr., A Mechanistic Study of the Reaction Between a Diiron(II) Complex [FeII2(m-OH)2(6-Me3-TPA)2]2+ and O2 to Form a Diiron(III) Peroxo Complex. Inorg. Chem. 2001, 40, 2220-2228 [Abstract]

Lehnert, N.; Ho, R. Y. N.; Que, L., Jr.; Solomon, E. I., "Spectroscopic Properties and Electronic Structure of Low-spin Fe(III)-Alkylperoxo Complexes: Homolytic Cleavage of the O-O Bond" J. Am. Chem. Soc. 2001, 123, 8271-8290. [Abstract]

Lehnert, N.; Ho, R. Y. N.; Que, L., Jr.; Solomon, E. I., "Electronic Structure of High-spin Fe(III)-Alkylperoxo Complexes and its Relation to Low-spin Analogs: Reaction Coordinate of O-O Bond Homolysis" J. Am. Chem. Soc. 2001, 123, 12802-12816. [Abstract]

Miyake, H; K. Chen; S. J. Lange; and L. Que, Jr., Intermolecular Trapping of a Nonheme Fe(IV)=O Intermediate. Inorg. Chem. 2001, 40, 3534-3538 [Abstract]

Que, L., Jr.; Watanabe, Y., Oxygenase pathways: oxo, peroxo and superoxo. Science 2001, 292, 651-653. [Publisher's Site]


2000

Costas, M.; Chen, K.; and Que, L. Jr. Biomimetic Nonheme Iron Catalysts for Alkane Hydroxylation. Coord. Chem. Rev. 2000, 200-202, 517-544.[Abstract]

DiDonato, M.; Hsu, H.-F.; Narindrasorasak, S.; Que, L. Jr.; and Sarkar, B. Copper-Induced Conformational Changes in the N-Terminal Domain of the Wilson Disease Copper-Transporting ATPase, Biochemistry; 2000, 39(7), 1890-1896.[Abstract]

Hagadorn, J. R.; Que, L. Jr.; and Tolman, W. B., N-Donor Effects on Carboxylate Binding in Mononuclear Iron(II) Complexes of a Sterically Hindered Benzoate Ligand. Inorg. Chem., 2000, 39, 6086-6090. [Publisher's web site]

Halfen, J. A.; Uhan, J. M.; Fox, D. C.; Mehn, M. P.; and Que, L. Jr., Copper(II) Complexes of Pyridyl-Appended Diazacycloalkanes: Syntheses, Characterization, and Application to Catalytic Olefin Aziridination. Inorg. Chem. 2000, 39, 4913-4920. [Publisher's web site]

Holland, P. L.; Cramer, C. J.; Wilkinson, E. C.; Mahapatra, S.; Rodgers, K. R.; Itoh, S.; Taki, M.; Fukuzumi, S.; Que, L. Jr.; and Tolman; W. B., Resonance Raman Spectroscopy as a Probe of the Bis(m-oxo)dicopper Core. J. Am. Chem. Soc., 2000, 122(5), 792-802.[Abstract]

Itoh, S.; Taki, M.; Nakao, H.; Holland, P. L.; Tolman, W. B.; Que, L. Jr.; and Fukuzumi, S., Aliphatic Hydroxylation by a Bis(mu-oxo)dicopper(III) Complex. Angew Chem., Int. Ed. Engl 2000, 39(2), 398-400.[Abstract]

Jo, D.-H., and Que, L. Jr., Tuning the Regiospecificity of Cleavage in Fe(III)-Catecholate Complexes: Tridentate Facial vs. Meridional Ligands. Angew. Chem. Int. Ed., 2000, 39, 4284-4287. [Publisher's web site]

Lehmann, T. E.; Serrano, M. L.; and Que, L. Jr., Coordination Chemistry of Co(II)-Bleomycin: Its Investigation through NMR and Molecular Dynamics. Biochemistry; 2000; 39(4), 3886-3898.[Abstract]

MacMurdo, V. L.; Zheng, H.; and Que, L. Jr., Model for the Cofactor Formation Reaction of E. Coli Ribonucleotide Reductase. From a Diiron(II) Precursor to an FeIIIFeIV Species via a Peroxo Intermediate. Inorg. Chem. 2000, 39(11), 2254-2255.[Publisher's web site]

Mandal, S. K.; Young, V. G. Jr.; and Que, L. Jr., Polynuclear Carboxylato-Bridged Iron(II) Clusters: Synthesis, Structure, and Host-Guest Chemistry. Inorg. Chem.; 2000, 39(8), 1831-1833.[Publisher's web site] 

Que, L. Jr., One motif — many different reactions, Nature Structural Biology, 2000, 7(3), 182-184.

Que, L. Jr., and Reynolds, M. F., Manganese(II)-dependent Extradiol-Cleaving Catechol Dioxygenases. Met. Ions Biol. Syst. 2000, 37, 505-25.

Roelfes, G.; Branum, M. E.; Wang, L.; Que, L. Jr.; and Feringa, B. L., Efficient DNA Cleavage with an Iron Complex Without Added Reductants. J. Am. Chem. Soc. 2000, 122, 11517-11518. [Abstract]

Roelfes, G.; Lubben, M.; Hage, R.; Que, L. Jr.; and Feringa, B. L., Catalytic oxidation with a non-heme iron complex that generates a low-spin FeIIIOOH intermediate.  Chem.--Eur. J.  2000, 6(12), 2152-2159. [Publisher's web site]

Zheng, H.; Yoo, S. J.; Münck, E.; and Que, L. Jr. The Flexible Fe2(m-O)2 Diamond Core: A Terminal Iron(IV)-Oxo Species Generated from the Oxidation of a Bis(m-oxo)diiron(III) Complex. J. Am. Chem. Soc., 2000, 122(15),  3789-3790.[Abstract]


1999

        1. “Raman Evidence for a Weakened O-O Bond in Mononuclear Low-Spin Iron(III)Hydroperoxides” 
R. Y. N. Ho, G. Roelfes, B. L.    Feringa, and L. Que, J
J. Am. Chem. Soc. 1999, 121, 264-265.
        2. “Differing Roles for the Diiron Clusters of Ribonucleotide Reductase from AerobicallyGrown Escherichia coli in the Generation of the Y122 Radical
       M. A. Miller, F. T. Gobena, K. Kauffmann, E. Münck, L.Que, Jr., and M. T.Stankovich,
       J. Am. Chem. Soc., 1999, 121, 1096-1097.
        3. "Oxygen Activation at Nonheme Iron Centers"
       L. Que, Jr.
       in "Bioinorganic Catalysis" 2nd ed. (J. Reedijk andE. Bouwman, eds.) Marcel Dekker, Inc., New York, 1999, pp.269-321.
        4. “Oxygen Activation and Arene Hydroxylation by Functional Mimics of alpha-KetoAcid-Dependent Iron(II) Dioxygenases
       E. L. Hegg, R. Y. N. Ho, and L. Que, Jr.,
       J. Am. Chem. Soc., 1999, 121, 1972-1973. 
        5. "Complexes with FeIII2(mu-O)(mu-OH), FeIII2(mu-O)2,and FeIII3(mu-O)3 Cores: Structures,Spectroscopy, and Core Interconversions",
       H. Zheng, Y. Zang, Y. Dong, V. G. Young, Jr., and L. Que, Jr.
       J. Am. Chem. Soc., 1999, 121, 2226-2235.
        6. "Enantioselective Epoxidation as a Probe for a Metal-Based Mechanism in H2O23-DependentOxidations Catalyzed by a Diiron Complex"
       C. Duboc-Toia, S. Ménage, R.Y. N. Ho, L. Que, Jr., C. Lambeaux, and M.Fontecave
       Inorg. Chem., 1999, 38, 1261-1268.
        7. "Iron Chemistry of the Pentadentate Ligand That Generates a Metastable FeIII-OOHIntermediate"
       G. Roelfes, M. Lubben, K. Chen, R. Y. N. Ho, A. Meetsma, S. Genseberger, R. M.Hermant, R. Hage, S. K. Mandal, V. G. Young, Jr., Y. Zang, H. Kooijman, A. L.Spek, L. Que, Jr., and B. L. Feringa"
       Inorg. Chem., 1999, 38, 1929-1936.
        8. “Crystal Structure of a Synthetic High-Valent Complex with an Fe2(mu-O)2Diamond Core. Implications for the Core Structures of Methane MonooxygenaseIntermediate Q and Ribonucleotide Reductase Intermediate X
       H.-F. Hsu, Y. Dong, L. Shu, V. G. Young, Jr., and L. Que, Jr.
       J. Am. Chem. Soc. 1999, 121, 5230-5237.
        9. "Role for the Nonheme Fe(II) Center in the Biosynthesis of the Plant Hormone Ethylene"
       M. Rocklin, D. L. Tierney, V. Kofman, N. M. W. Brunhuber, B. M. Hoffman, R. E.Christoffersen, N. O.Reich, J. D. Lipscomb, and L. Que, Jr.
       Proc. Natl. Acad Sci. USA, 1999, 96, 7905-7909.
        10. “Evidence for a Nonheme Fe(IV)=O Species in the Intramolecular Hydroxylation of a PhenylMoiety
       S. J. Lange, H. Miyake, and L. Que, Jr.
       J. Am. Chem. Soc. 1999, 121, 6330-6331.
        11. “Evidence for the Participation of a High-Valent Iron-Oxo Species in StereospecificAlkane Hydroxylation by a Nonheme Iron Catalyst
       K. Chen and L. Que, Jr.
       Chem. Commun. 1999, 1375-1376. [SupprotingInfo (txt)]
        12."cis-Dihydroxylation of Olefins by a Nonheme Iron Catalyst. AFunctional Model for Rieske Dioxygenases"
       K. Chen and L. Que, Jr.
       Angew. Chem. Int. Ed., 1999, 38, 2227-2229.
        13. “EPR Properties of Mixed-Valent mu-Oxo and m-Hydroxo Dinuclear Iron ComplexesProduced by Radiolytic Reduction at 77 K
       R. M. Davydov, J. Smieja, S. A. Dikanov, Y. Zang, L. Que, Jr., and M. K. Bowman
       J. Biol. Inorg. Chem. 1999, 4, 292-301.
        14. “Double-strand DNA Hydrolysis by Dilanthanide Complexes
       M. E. Branum and L. Que, Jr., J. Biol. Inorg. Chem.1999, 4(5),593-600.
        15. "Herbicide-Degrading-Keto Acid-Dependent Enzyme TfdA: Metal Coordination Environment andMechanistic Insights"
        Hegg, E. L., Whiting, A. K., Saari,R. E., McCracken, J., Hausinger, R. P., Que, L., Jr.
        Biochemistry; 1999, 38(50),16714-16726.
        16. "Conformational Tuningof Valence Delocalization in Carboxylate-Rich Diiron Complexes"
        Hagadorn, J. R., Que, L., Jr.,Tolman, W. B., Prisecaru, I., Munck, E.
        J. Am. Chem. Soc., 1999;121(41); 9760-9761.
        17. "Spectroscopic Characterization of a Ternary Phosphatase-Substrate-Fluoride Complex.Mechanistic Implications for Dinuclear Hydrolases"
        Wang, X., Ho, R. Y. N., Whiting, A.K., Que, L., Jr.
       J. Am. Chem. Soc., 1999, 121(39), 9235-9236.
 

1998

    1. "EXAFS Characterization of the Intermediate X Generated during the Assembly of the E. coli Ribonucleotide Reductase R2 Diferric-Tyrosyl Radical Cofactor", P. J. Riggs-Gelasco, L. Shu, S. Chen, D. Burdi, B. H. Huynh, L. Que, Jr., and J. Stubbe J. Am. Chem. Soc. 1998, 120, 849-860.
    2. "Raman Signature of the Fe2O2 "Diamond" Core", E. C. Wilkinson, Y. Dong, Y. Zamg, H. Fujii, R. Fraczkiewicz, R. S. Czernuszewicz, and L. Que, Jr. J. Am. Chem. Soc. 1998, 120, 955-962.
    3. "Unexpected Assembly of a (m-Oxo)(m-formato)diiron(III) Complex from an Aerobic Methanolic Solution of Fe(III) and the TPA Ligand", R. E. Norman, R. A. Leising, S. Yan, and L. Que, Jr. Inorg. Chim. Acta 1998, 273, 393-396.
    4. "Oxygen Activating Nonheme Iron Enzymes", S. J. Lange and L. Que. Jr. Curr. Op. Chem. Biol. 1998, 2, 159-172.
    5. "The High Valent Nonheme Fe2O2 Diamond Core: Comparisons with the Heme Ferryl", L. Que, Jr. Pure & Appl. Chem. 1998, 70, 947-954.
    6. "Spectroscopic Signatures of the Fe2O2 Diamond Core", L. Que, Jr., Y. Dong, L. Shu, and E. C. Wilkinson ACS Symp. Ser. 1998, 692, 374-386.
    7. "Extended X-ray Absorption Fine Structure Studies of the Anion Complexes of FeZn Uterfoerrin", X. Wang and L. Que, Jr. Biochemistry 1998, 21, 7813-7821.
    8. "EXAFS and Mössbauer Characterization of the Diiron(III) Site in Stearoyl-Acyl-Carrier-Protein (ACP) Desaturase", L. Shu, J. A. Broadwater, C. Achim, B. G. Fox, E. Münck, and L. Que, Jr. J. Biol. Inorg. Chem. 1998, 3, 392-400.
    9. "Mössbauer Evidence for Antisymmetric Exchange in a Diferric Synthetic Complex and Diferric Methane Monooxygenase", K. E. Kauffmann, C. V. Popescu, Y. Dong, J. D. Lipscomb, L. Que, Jr., and E. Münck, J. Am. Chem. Soc. 1998, 120, 8739-8746.
    10. "MMO: P450 in Wolf's Clothing?", J. D. Lipscomb, L. Que, Jr. J. Biol. Inorg. Chem. 1998, 3, 331-336.
    11. “A Bulky Benzoate Ligand for Modeling the Carboxylate-Rich Active Sites of Non-Heme Diiron Enzymes”, J. R. Hagadorn, L. Que, Jr., and W. B. Tolman, J. Am. Chem. Soc. 1998,120,13531-13532.

 


1997

    1. "An FeIV2O2 Diamond Core Structure for the Key Intermediate Q of Methane Monooxygenase", L. Shu, J. Nesheim, K. Kauffmann, E. Münck, J. D. Lipscomb, and L. Que, Jr. Science 1997, 275, 515-518.
    2. "Manganese(II) Active Site Mutants of 3,4-Dihydroxyphenylacetate 2,3-Dioxygenase from Arthrobacter globiformis strain CM-2", Y. R. Boldt, A. K. Whiting, M. L. Wagner, M. J. Sadowsky, L. Que, Jr., and L. P. Wackett Biochemistry1997, 36, 2147-2153.
    3. "NMR Studies of the Paramagnetic Complex Fe(II)-Bleomycin", T. Lehmann, L.-J. Ming, M. E. Rosen, and L. Que, Jr. Biochemistry 1997, 36, 2807-2816.
    4. "Metal Coordination Environment of a Cu(II)-Substituted a-Keto Acid-Dependent Dioxygenase That Degrades the Herbicide 2,4-D", A. K. Whiting, L., Que, Jr., R. E. Saari, R. P. Hausinger, M. A. Fredrick, and J. McCracken J. Am. Chem. Soc. 1997, 119, 3413-3414.
    5. "Modeling Nonheme Diiron Enzymes: Hydrocarbon Hydroxylation and Desaturation by a High-Valent Fe2O2 Diamond Core", C. Kim, Y. Dong and L. Que, Jr. J. Am. Chem. Soc.1997, 119, 3635-3636.
    6. "Proton NMR Studies of Myohemerythrin from Themiste zostericola", Z. Wang, L. Martins, W. R. Ellis, Jr., and L. Que, Jr. J. Biol. Inorg. Chem. 1997, 2, 56-64.
    7. "Fe(TPA)-Catalyzed Alkane Hydroxylation Can Be a Metal-Based Oxidation", J. Kim, C. Kim, R. G. Harrison, E. C. Wilkinson, and L. Que, Jr. J. Mol. Cat. A: Chem. 1997, 117, 83-89.
    8. "Functional Models for Iron-Bleomycin", G. Roelfes, M. Lubben, S. W. Leppard, E. P. Schudde, R. M. Hermant, R. Hage, E. C. Wilkinson, L. Que, Jr., and B. L. Feringa J. Mol. Cat. A: Chem.. 1997, 117, 223-227.
    9. "Dioxygen Binding at Ambient Temperature: Formation of a Novel Peroxodicopper(II) Complex with an Azole Macrocyclic Ligand", J. E. Bol., W. L. Driessen, R. Y. N. Ho, B. Maase, L. Que, Jr., and J. Reedjik Angew. Chem. Int. Ed. Engl. 1997, 36, 998-1000.
    10. "Models for Nonheme Iron Intermediates: The Structural Basis for Tuning the Spin States of Fe(TPA) Complexes", Y. Zang, J. Kim, Y. Dong, E. C. Wilkinson, E. H. Appelman, and L. Que, Jr. J. Am. Chem. Soc. 1997, 119, 4197-4205.
    11. "Biomimetic Extradiol Cleavage of Catechols: Insights into the Enzyme Mechanism", M. Ito and L. Que, Jr. Angew. Chem. Int. Ed. Engl. 1997, 36, 1342-1344.
    12. "Stereospecific Alkane Hydroxylation with H2O2 Catalyzed by an Fe(II) TPA Complex", C. Kim, K. Chen, J. Kim, and L. Que, Jr. J. Am. Chem. Soc. 1997, 119, 5964-5965.
    13. "Synthetic Models of the Inactive Copper(II)-Tyrosinate and Active Copper(II)-Tyrosyl Radical Forms of Galactose and Glyoxal Oxidases", J. A. Halfen, B. A. Jazdzewski, S. Mahapatra, L. M. Berreau, E. C. Wilkinson, L. Que, Jr., and W. B. Tolman J. Am. Chem. Soc. 1997, 119, 8217-8227.
    14. "Crystal Structure and Resonance Raman Studies of Protocatechuate 3,4-dioxygenase Complexed with 3,4-Dihydroxyphenylacetate", T. E. Elgren, A. M. Orville, K. A. Kelly, J. D. Lipscomb, D. H. Ohlendorf, L. Que, Jr. Biochemistry1997, 36, 11504-11513.
    15. "Cu(II)-a-Keto Acid Complexes as Structural Models of a-Keto Acid-Dependent Enzymes: Syntheses, Crystal Structure and Properties of [Cu(L) (benzoylformate)]X", H. Zheng and L. Que, Jr. Inorg. Chim. Acta 1997, 263, 301-307.
    16. "A Putative Monooxygenase Mimic Which Functions via Well-Disguised Free Radical Chemistry", P. A. MacFaul, K. U. Ingold, D. D. M. Wayner, and L. Que, Jr. J. Am. Chem. Soc. 1997, 119, 10594-10598.
    17. "Oxygen Activation at Non-Heme Diiron Active Sites in Biology: Lessons from Model Complexes", L. Que, Jr. J. Chem. Soc., Dalton Trans. 1997, 3933-3940.
    18. "Models for Amide Ligation in Nonheme Iron Enzymes", S. K. Mandal and L. Que, Jr. Inorg. Chem. 1997, 36, 5424-5425.
    19. "Models for Nonheme Diiron Enzymes. Assembly of a High-Valent Fe2(m-O)2 Diamond Core from Its Peroxo Precursor", Y. Dong, Y. Zang, L. Shu, E. C. Wilkinson, L. Que, Jr., K. Kauffmann, and E. Münck J. Am. Chem. Soc. 1997, 119, 12683-12684.
    20. "The 2-His-1-Carboxylate Facial Triad. An Emerging Structural Motif in Mononuclear Non-Heme Iron(II) Enzymes", E. Hegg and L. Que, Jr. Eur. J. Biochem. 1997, 250, 625-629.

 


1996

    1. "Crystal Structure Analysis of a Synthetic Non-Heme Diiron-O2 Adduct: Insight into the Mechanism of Oxygen Activation", Dong, Y.; Yan, S.; Young, V. G., Jr.; Que, L., Jr. Angew. Chem. Int. Ed. Engl. 1996, 35, 618-620.
    2. "Electronic Strucutre of Non-Heme High-Valent Oxoiron Complexes with the Unprecedented [Fe2m-O.2]3+ Core", Ghosh, A.; Almlöf, J.; Que, L., Jr. Angew. Chemn. Int. Ed. Engl. 1996, 35, 770-772.
    3. "Synthetic Modeling of Nitrite Binding and Activation by Reduced Copper Proteins. Characterization of CopperI.-Nitrite Complexes That Evolve Nitric Oxide", Halfen, J. A.; Mahapatra, S.; Wilkinson, E. C.; Gengenbach, A. J.; Young, V. G., Jr.; Que, L., Jr. J. Am. Chem. Soc. 1996, 118, 763-776.
    4. "Structural, Spectroscopic, and Theoretical Characterization of Bism-oxo.dicopper Complexes, Novel Intermediates in Copper-Mediated Dioxygen Activation", Mahapatra, S.; Halfen, J. A.; Wilkinson, E. C.; Pan, G.; Wang, X.; Young, V. G., Jr.; Cramer, C. J.; Que, L., Jr.; Tolman, W. B. J. Am. Chem. Soc. 1996, 118, 11555-11574.
    5. "Modeling the Oxygen Activation Chemistry of Methane Monooxygenase and Ribonucleotide Reductase", Que, L., Jr.; Dong, Y. Acc. Chem. Res. 1996, 29, 190-196.
    6. "X-Ray Absorption Spectroscopic Studies of the Methane Monooxygenase Hydroxylase Component from Methylosinus trichosporium OB3b", Shu, L.; Liu, Y.; Lipscomb, J. D.; Que, L., Jr. JBIC 1996, 1, 297-304.
    7. "ManganeseII.-Dependent Extradiol-Cleaving Catechol Dioxygenase from Arthrobacter globiformis CM-2", Whiting, A. K.; Boldt, Y. R.; Hendrich, M. P.; Wackett, L. P.; Que, L., Jr. Biochemistry 1996, 35, 160-170.
    8. "DirronII. Complexes of Some Relevance to the Purple Acid Phosphatases", Yan, S.; Pan, X.; Taylor, L. F.; Zhang, J. H.; O'Connor, C. J.; britton, D.; Anderson, O. P.; Que, L., Jr. Inorg. Chim. Acta 1996, 243, 1-8.
    9. "Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites", Que, L., Jr.; Ho, R. Y. N. Chem. Rev. 1996, 96, 2607-2624.

 


1993-95

    1. "Dioxygen Binding to Diferrous Centers. Models for Diiron-Oxo Proteins", Dong, Y.; Ménage, S.; Brennan, B. A.; Elgren, T. E.; Jang, H. G.; Pearce, L. L.; Que, L., Jr. J. Am. Chem. Soc. 1993, 115, 1851-1859.
    2. "X-ray Absorption Studies of the Ferrous Active Site of Isopenicillin N Synthase and Related Model Complexes", Randall, C. R.; Zang, Y.; True, A. E.; Que, L., Jr.; Charnock, J. M.; Garner, C. D.; Fujishima, Y.; Schofield, C. J.; Baldwin, J. E. Biochemistry 1993, 32, 6664-6673.
    3. "A High-Potential Ferrous Complex and Its Conversion to an AlkylperoxoironIII. Intermediate. A Lipoxygenase Model", Zang, Y.; Elgren, T. E.; Dong, Y.; Que, L., Jr. J. Am. Chem. Soc. 1993, 115, 811-813.
    4. "Spectroscopic and Electrochemical Properties of m-Oxo.diironIII. Complexes Related to diiron-Oxo Proteins. Structure of [Fe2OTPA.2MoO4.]ClO4.2", Holz, R. C.; Elgren, T. E.; Pearce, L. L.; Zhang, J. H.; O'Connor, C. J.; Que, L., Jr. Inorg. Chem. 1993, 32, 5844-5850.
    5. "Alkane Functionalization at Nonheme Iron Centers. Stoichiometric Transfer of Metal-Bound Ligands to Alkane", Kojima, T.; Leising, R. A.; Yan, S.; Que, L., Jr. J. Am. Chem. Soc. 1993, 115, 11328-11335.
    6. "Azide Binding to the Diferrous Clusters of the R2 Protein of Ribonucleotide Reductase from Escherichia coli", Hendrich, M. P.; Elgren, T. E.; Que, L., Jr. J. Am. Chem. Soc. 1993, 115, 9291-9292.
    7. "Alkane Functionalization at m-Oxo.diironIII. Centers", Leising, R. A.; Kim, J.; Pérez, M. A.; Que, L., Jr. J. Am. Chem. Soc. 1993, 115, 9524-9530.
    8. "Two-Dimensional 1H NMR Studies of Paramagnetic Bimetallic Mixed-Metal Complexes", Wang, Z.; Holman, T. R.; Que, J. L. Mag. Resonance in Chem. 1993, 31, S78-S84.
    9. "Models for a-keto acid-dependent nonheme iron enzymes", Chiou, Y.-M.; Que, L., Jr. J. Inorg. Biochem. 1993, 51, 127.
    10. "Structure and Reactivity of a Bism-acetato-O,O'.diironII. Complex, [Fe2TPA.2MoO4.]BPh4.2. A Model for the Diferrous Core of Ribonucleotide Reductase", Holz, R. C.; Elgren, T. E.; Pearce, L. L.; Zhang, J. H.; O'Connor, C. J.; Que, L., Jr. Inorg. Chem. 1993, 32, 5844-5850.
    11. "g =16 EPR signal", Jang, H. G.; Hendrich, M. P.; Que, L., Jr. Inorg. Chem. 1993, 32, 911-918.
    12. "Alkane functionalization OLT.", Kojima, T.; Leising, R. A.; Yan, S.; Que, L., Jr. J. Am. Chem. Soc. 1993, 115, 11328-11335.
    13. Que, L., Jr., "Oxygen Activation at Nonheme Iron Centers" In Bioinorganic Catalysis; J. Reedijk, Ed.; Marcel Dekker: New York, 1993; pp 347-393.
    14. "2D NMR", Wang, Z.; Holman, T. R.; Que, L., Jr. Mag. Reson. Chem. 1993, 31, S78-S84.
    15. "Structures and Properties of Ferromagnetically Coupled Bism-halo.diironII. Complexes", Zang, Y.; Jang, H. G.; Chiou, Y.-M.; Hendrich, M. P.; Que, L., Jr. Inorg. Chim. Acta 1993, 213, 41-48.
    16. "Crystallization of Catechol-1,2-Dioxygenase from Pseudomonas arvilla C-1", Earhart, C. A.; Hall, M. D.; Michaud-Soret, I.; Que, L., J.r; Ohlendorf, D. H. J. Mol. Biol. 1994, 236, 377-378.
    17. "Modeling Hydrolysis at Dinuclear Iron Centers", Wilkinson, E. C.; Dong, Y.; Que, L., Jr. J. Am. Chem. Soc. 1994, 116, in press.
    18. "First Diferric Complex with an Fe2m-O.m-OH. Core. Structure and Reactivity of [Fe2m-O.m-OH.6TLA.2]ClO4.3", Zang, Y.; Pan, G.; Que, L., Jr.; Fox, B. G.; Münck, E. J. Am. Chem. Soc. 1994, 116, 3653-3654.
    19. "A Model for a-Keto Acid Dependent Nonheme Iron Enzymes: Structure and Reactivity of [FeII2Me2hdp.2bf.]ClO4.", Chiou, Y.-M.; Que, L. J. Angew. Chem. Int. Ed. Engl. 1994, 33, 1886-1888.
    20. "Spectroscopic Studies of CoII.-Reconstituted Ribonucleotide Reductase R2 from Escherichia coli", Elgren, T. E.; Ming, L.-J.; Que, J. L. Inorg. Chem. 1994, 33, 891-894.
    21. "Density Functional Theoretical Study of Oxoporphyrinato.ironIV. Complexes, Models of Peroxidase Compounds I and II1", Ghosh, A.; Almlöf, J.; Que, J. L. J. Phys. Chem. 1994, 98, 5576-5579.
    22. "Modeling Copper-Dioxygen Reactivity in Proteins: Aliphatic C-H Bond Activation by a New DicopperII.-Peroxo Complex", Mahapatra, S.; Halfen, J. A.; Wilkinson, E. C.; Que, L., Jr.; Tolman, W. B. J. Am. Chem. Soc. 1994, 116, 9785-9786.
    23. "CarboxylatoironII. Aggregates: A Novel FeII4 Complex with Threefold Symmetry", Ménage, S.; Fujii, H.; Hendrich, M. P.; Que, J. L. Angew. Chem. Int. Ed. Engl. 1994, 33, 1660-1662.
    24. "One- and Two-Dimensional 1H NMR Studies of the Active Site of IronII. Superoxide Dismutase from Escherichia coli", Ming, L.-J.; Lynch, J. B.; Holz, R. C.; Que, J. L. Inorg. Chem. 1994, 33, 83-87.
    25. "Double-Stranded Cleavage of pBR322 by a Diiron Complex via a "Hydrolytic" Mechanism", Schnaith, L. M. T.; Hanson, R. S.; Que, J. L. Proc. Natl. Acad. Sci. USA 1994, 91, 569-573.
    26. "[Fe2O.OH.6TLA.2]ClO4.3", Zang, Y.; Pan, G.; Que, L., Jr.; Fox, B. G.; Münck, E. J. Am. Chem. Soc. 1994, 116, 3653-3654.
    27. "Structural and Spectroscopic Properties of Antiferromagnetically Coupled FeIIIMnII and FeIIMnII Complexes", Holman, T. R.; Wang, Z.; Hendrich, M. P.; Que, J. L. Inorg. Chem. 1995, 34, 134-139.
    28. "The First Bism-oxo.diironIII. Complex. Structure and Magnetic Properties of [Fe2m-O.26TLA.2]ClO4.2", Zang, Y.; Dong, Y.; Que, L., Jr.; Kauffmann, K.; Münck, E. J. Am. Chem. Soc. 1995, 117, 1169-1170.
    29. "A High-Valent Nonheme Iron Intermediate. Structure and Properties of [Fe2m-O.25-Me-TPA.2]ClO4.3", Dong, Y.; Fujii, H.; Hendrich, M. P.; Leising, R. A.; Pan, G.; Randall, C. R.; Wilkinson, E. C.; Zang, Y.; Que, L., Jr.; Fox, B. G.; Kauffmann, K.; Münck, E. J. Am. Chem. Soc. 1995, 117, 2778-2792.
    30. "Structure and Reactivity of FeII.-SAr Complexes: Relevance to the Active Site of Isopenicillin N Synthase", Zang, Y.; Que, L., Jr. Inorg. Chem. 1995, 34, 1030-1035.
    31. "Models for a-Keto Acid-Dependent Nonheme Iron Enzymes: Structures and Reactivity of [FeIIL.O2CCOPh.]ClO4. Complexes", Chiou, Y.-M.; Que, L., Jr. J. Am. Chem. Soc. 1995, 117, 3999-4013.
    32. "A Manganese-Dependent Dioxygenase from Arthrobacter globiformis strain CM-2 Belongs to the Major Extradiol Dioxygenase Family", Boldt, Y. R.; Sadowsky, M. J.; Ellis, L. B. M.; Que, L., Jr.; Wackett, L. P. J. Bacteriol. 1995, 177, 1225-1232.
    33. "X-ray Absorption Spectroscopic Studies of the FeII. Active Site of Catechol 2,3-Dioxygenase. Implications for the Extradiol Cleavage Mechanism", Shu, L.; Chiou, Y.-M.; Orville, A. M.; Miller, M. A.; Lipscomb, J. D.; Que, L., Jr. Biochemistry 1995, 34, 6649-6659.
    34. "Structure of a Mononuclear IronII.-Catecholate Complex and Its Relevance to the Extradiol-Cleaving Catechol Dioxygenases", Chiou, Y.-M.; Que, L., Jr. Inorg. Chem. 1995, 34, 3577-3578.
    35. "An AlkylperoxoironIII. Intermediate and Its Role in the Oxidation of Aliphatic C-H Bonds", Kim, J.; Larka, E.; Wilkinson, E. C.; Que, L., Jr. Angew. Chem. Int. Ed. Eng. 1995, 34, 2048-2049.
    36. "Nonheme Iron Centers in Oxygen Activation: Characterization of an IronIII. Hydroperoxide Intermediate", Lubben, M.; Meetsma, A.; Wilkinson, E. C.; Feringa, B.; Que, L., Jr. Angew. Chem. Int. Ed. Engl. 1995, 34, 1512-1514.
    37. "A New Intermediate in Copper Dioxygen Chemistry: Breaking the O-O Bond To Form a {Cu2m-O.2}2+ Core", Mahapatra, M.; Halfen, J. A.; Wilkinson, E. C.; Pan, G.; Cramer, C. J.; Que, L., Jr.; Tolman, W. B. J. Am. Chem. Soc. 1995, 117, 8865-8866.
    38. "Formation of an AlkylperoxoironIII. Complex During Oxidations Catalyzed by m-OxodiironIII. Complexes", Ménage, S.; Wilkinson, E. C.; Que, L., Jr.; Fontecave, M. Angew. Chem. Int. Ed. Engl. 1995, 34, 203-205.
    39. "Resonance Raman Studies of Catecholate and Phenolate Complexes of Recombinant Human Tyrosine Hydroxylase", Michaud-Soret, I.; Andersson, K. K.; Que, L., Jr. Biochemistry 1995, 34, 5504-5510.
    40. "Residues Important for Radical Stability in Ribonucleotide Reductase from Escherichia coli", Ormö, M.; Regnström, K.; Wang, Z.; Que, L., Jr.; Sahlin, M.; Sjöberg, B.-M. J. Biol. Chem. 1995, 270, 6570-6576.
    41. "L-Edge X-ray Absorption and X-ray Magnetic Circular Dichroism of Oxygen-Bridged Dinuclear Iron Complexes", Peng, G.; Elp, J. v.; Jang, H.; Que, L., Jr.; Armstrong, W. H.; Cramer, S. P. J. Am. Chem. Soc. 1995, 117, 2515-2519.
    42. Que, L., Jr., "Oxygen Activation at Nonheme Iron Centers" In Active Oxygen in Biochemistry; J. S. Valentine, C. S. Foote, A. Greenberg and J. F. Liebman, Ed.; Blackie A & P: Glasgow, 1995; Vol. 3; pp 232-275.
    43. "X-ray Absorption Pre-Edge Studies of High-Spin IronII. Complexes", Randall, C. R.; Shu, L.; Chiou, Y.-M.; Hagen, K. S.; M. Ito, N. K.; Lachicotte, R. J.; Zang, Y.; Que, L., Jr. Inorg. Chem. 1995, 34, 1036-1039.
    44. Wang, Z.; Que, L., Jr., "NMR Studies of Nonheme Iron Proteins" In Nuclear Magnetic Resonance of Paramagnetic Macromolecules; G. N. La Mar, Ed.; Kluwer Academic Publishers: Dordrecht, 1995; Vol. 457; pp 193-211.
    45. "Structure and Reactivity of FeII.-SAr Complexes: Relevance to the Active Site of Isopenicillin N Synthase", Zang, Y.; Que, L., Jr. Inorg. Chem. 1995, 34, 1030-1035.
    46. "Reaction of NO with the Reduced R2 Protein of Ribonucleotide Reductase from Escherichia coli", Haskin, C. J.; Ravi, N.; Lynch, J. B.; Münck, E.; Que, L., Jr. Biochemistry 1995, 34, 11090-11098.
    47. "Reaction of NO with the Reduced R2 Protein of Ribonucleotide Reductase from Escherichia coli", Haskin, C. J.; Ravi, N.; Lynch, J. B.; Münck, E.; Que, L., Jr. Biochemistry 1995, 34, 11090-11098.

1990-92

1. "Coordination Chemistry of theMetal Binding Site of Isopenicillin N Synthase", Ming, L.-J.; Que, L.,Jr.; Kriauciunas, A.; Frolik, C. A.; Chen, V. J. Inorg. Chem. 1990, 29,1111-1112.
2. "Models for Diferrous Forms of Iron-Oxo Proteins. Structure andProperties of   [Fe2BPMPO2CR.2]BPh4 Complexes", Borovik, A. S.;Hendrich, M. P.; Holman, T. R.;  Que, L., Jr.; Papaefthymiou, V.; Münck,E. J. Am. Chem. Soc. 1990, 112, 6031-6038.
3. "Alkane Functionalization by Non-Porphyrin Iron Complexes: MechanisticInsights",  Leising, R. A.; Norman, R. E.; Que, L., Jr. Inorg. Chem.1990, 29, 2553-2555.
4. "Models for Iron-Oxo Proteins: Dioxygen Binding to a DiferrousComplex", Ménage, S.; Brennan, B. A.; Juarez-Garcia, C.; Münck, E.; Que,L., Jr. J. Am. Chem. Soc. 1990, 112, 6423-6425.
5. "m-Oxo m-carboxylato diironIII Complexes with Distinct Iron Sites.Consequences of  the Inequivalence and Its Relevance to Dinuclear Iron-OxoProteins", Norman, R. E.;  Yan, S.; Que, L., Jr.; Sanders-Loehr, J.;Backes, G.; Ling, J.; Zhang, J. H.; O'Connor, C.  J. J. Am. Chem. Soc.1990, 112, 1554-1562.
6. Que, L., Jr.; True, A. E., "Dinuclear Iron- and Manganese-Oxo Sites inBiology" In Prog. Inorg. Chem.; S. J. Lippard, Ed.; John Wiley & Sons:New York, 1990; Vol. 38; pp 97-200.
7. "A Bism-alkoxo.diiron Complex with Novel Terminally LigatedCarboxylates",  Ménage, S.; Que, L., Jr. Inorg. Chem. 1990, 29,4293-4297.
8. "Correlations Between Magetism and Structure in Dinuclear CuIIFeIIIComplexes with Integer Spin EPR Signals", Holman, T. R.; Andersen, K. A.;Anderson, O. P.; Hendrich, M. P.; Juarez-Garcia, C.; Münck, E.; Que, L., Jr.Angew. Chem. Intl. Ed. Engl. 1990, 29, 921-923.
9. "Models for Diferrous Forms of Iron-Oxo Proteins. Structure andProperties of    [Fe2BPMPO2CR.2]BPh4Complexes", Borovik, A. S.; Hendrich, M. P.; Holman, T. R.;  Münck,E.; Papaefthymiou, V.; Que, L., Jr. J. Am. Chem. Soc. 1990, 112, 6031-6038.
10. "Mössbauer and EPR Study of an Antiferromagnetically Coupled FeIIINiIIComplex", Holman, T. R.; Juarez-Garcia, C.; Hendrich, M. P.; Que, L., Jr.;Münck, E. Inorg. Chem. 1990, 31, 937-939.
11. "FeIIICuII Complexes with integer spin EPRsignals", Holman, T. R.; Anderson, K. A.; Anderson, O. P.; Hendrich, M.P.; Juarez-Garcia, C.; Münck, E.; Que, L., Jr. Angew. Chem. Int. Ed. Engl.1990, 29, 921-923.
12. Leising, R. A.; Norman, R. E.; Que, L., Jr. Inorg. Chem. 1990, 29,2553-2555.
13. "m-Oxo.m-carboxylato.diironIII. Complexes with Distinct Iron Sites.onsequences of the Inequivalence and Its Relevance to Dinuclear Iron-OxoProteins", Norman, R. E.; Yan, S.; Que, L., Jr.; Backes, G.; Ling, J.;Sanders-Loehr, J.; Zhang, J. H.; O'Connor, C. J. J. Am. Chem. Soc. 1990, 112,1554-1562.
14. "Structures and Properties of Dibridged m-oxo.diiron Complexes.Effects of the    Fe-O-Fe Angle", Norman, R. E.; Holz, R.C.; Ménage, S.; O'Connor, C. J.; Zhang, J. H.; Que, J., L. Inorg. Chem. 1990,29, 4629-4637.
15. "An EXAFS Study of the Interaction of Substrate with the Ferric ActiveSite of  Protocatechuate 3,4-Dioxygenase", True, A. E.; Orville, A.M.; Pearce, L. L.; Lipscomb, J. D.; Que, L., Jr. Biochemistry 1990, 29,10847-10854.
16. "Magnetostructural Correlations of Dinuclear CuII.FeIII. Complexeswith Integer Spin EPR Signals", Holman, T. R.; Andersen, K. A.; Anderson,O. P.; Hendrich, M. P.; Juarez-Garcia, C.; Münck, E.; Que, L., Jr. Angew. Chem.Intl. Ed. Engl. 1990, 29, 921-923.
17. "Models for Iron-Oxo Proteins. Mössbauer and EPR Study of anAntiferromagnetically Coupled FeIIINiII Complex", Holman, T. R.;Juarez-Garcia, C.; Hendrich, M. P.; Que, L., Jr.; Münck, E. J. Am. Chem. Soc.1990, 112, 7611-7618.
18. Models for Non-Heme Iron Oxygenases: A High-Valent Iron-OxoIntermediate", Leising, R. A.; Brennan, B. A.; Que, L., Jr.; Fox, B. G.;Münck, E. J. Am. Chem. Soc. 1991, 113, 3988-3990.
19. "Electron Transfer Associated with Oxygen Activation in the B2 Proteinof    Ribonucleotide Reductase from Escherichia coli",Elgren, T. E.; Lynch, J. B.;    Juarez-Garcia, C.; Münck, E.;Sjöberg, B.-M.; Que, L., Jr. J. Biol. Chem. 1991, 266, 19265-19268.
20. "m-Oxo.m-carboxylato.DiironIII. Complexes. Effects of the TerminalLigands", Ménage, S.; Que, L., Jr New. J. Chem. 1991, 15, 431-438.
21."Oxidative Ligand Transfer to Alkanes: A Model for Iron-MediatedC&endash; X Bond Formation in b-Lactam Antibiotic Biosynthesis",Leising, R. A.; Zang, Y.; Que, L., Jr. J. Am. Chem. Soc. 1991, 113, 8555-8557.
22. "NMR Studies of the Active Site of Isopenicillin N Synthase, aNon-Heme IronII. Enzyme", Ming, L.-J.; Que, L., Jr.; Kriauciunas, A.;Frolik, C. A.; Chen, V. J. Biochemistry 1991, 30, 11653-11659.
23. "Models for Diiron-Oxo Proteins: The Peroxide Adduct ofFe2HPTB.OH.NO3.4", Brennan, B. A.; Chen, Q.; Juarez-Garcia, C.; True, A.E.; O'Connor, C. J.; Que, L., Jr. Inorg. Chem. 1991, 30, 1937-1943.
24. "Electron Spin Echo Envelope Modulation Studies of theCuII.-Substituted Derivative of Isopenicillin N Synthase: A Structural andSpectroscopic Model", Jiang, F.; Peisach, J.; Ming, L.-J.; Que, L., Jr.;Chen, V. J. Biochemistry 1991, 30, 11437-11445. 25."Oxygen Activation atthe Diiron Center of Ribonucleotide Reductase", Que, L., Jr. Science 1991,253, 273-274.
26. "Combined Mössbauer and EPR Studies of the S = 3 State of anExchange-Coupled FeIIICuII Complex: Test for Quantitative EPR Analysis of IntegerSpin Systems", Juarez-Garcia, C.; Hendrich, M. P.; Holman, T. R.; Que, L.,Jr.; Münck, E. J. Am. Chem. Soc. 1991, 113, 518-525.
27. "Models for Diiron-Oxo Proteins: The Peroxide Adduct ofFe2HPTB.OH.NO3.4", Brennan, B. A.; Chen, Q.; Juarez-Garcia, C.; True, A.E.; O'Connor, C. J.; Que, L., Jr. Inorg. Chem. 1991, 30, 1937-1943.
28. Elgren, T. E.; Lynch, J. B.; Juarez-Garcia, C.; Münck, E.; Sjöberg, B.-M.;Que, L., Jr. J. Biol. Chem. 1991, in press
29. "Multifield Saturation Magnetization and Multifrequency EPRMeasurements of    Deoxyhemerythrin Azide. A UnifiedPicture", Hendrich, M. P.; Pearce, L. L.; Que, L., Jr.; Chasteen, N. D.;Day, E. P. J. Am. Chem. Soc. 1991, 113, 3039-3044. 30. "A Highly ReactiveFunctional Model for the Catechol Dioxygenases. Structure and Properties of[FeTPA.DBC]BPh4", Jang, H. G.; Cox, D. D.; Que, L., Jr. J. Am. Chem. Soc.1991, 113, 9200-9204.
31. "FeIIICuII complex: S = 3", Juarez-Garcia, C.; Hendrich, M. P.;Holman, T. R.; Que, L., Jr.; Münck, E. J. Am. Chem. Soc. 1991, 113, 518-525.
32. "Models for Catechol Dioxygenases. Structure ofBromobis[2-2'-hydroxyphenyl.benzothiazolato]ironIII. Derived from theBromoironIII. Complex of 2,2'-Bissalicylideneamino.phenyl. Disulfide",Pyrz, J.; Pan, X.; Britton, D.; Que, L., Jr. Inorg. Chem. 1991, 30, 3461-3564.
33. "Multifield Saturation and Multifrequency EPR Measurements ofDeoxyhemerythrin Azide: A Unified Picture", Hendrich, M. P.; Pearce, L.L.; Que, L., Jr.; Chasteen, N. D.; Day, E. P. J. Am. Chem. Soc. 1991, 113,3039-3044.
34. "Structure and Reactivity of a Bism-acetato-O,O'.diironII. Complex,[Fe2O2CCH3.2TPA.2]BPh4.2. A Model for the Diferrous Core of RibonucleotideReductase", Ménage, S.; Zang, Y.; Hendrich, M. P.; Que, L., Jr. J. Am.Chem. Soc.  1992, 114, 7786-7792.
35. "Resonance Raman Studies of the Protocatechuate 3,4-Dioxygenasefrom    Brevibacterium fuscum", Siu, D. C.-T.; Orville, A.M.; Lipscomb, J. D.; Ohlendorf, D. H.; Que, L., Jr. Biochemistry 1992, 31,10443-10448.
36. "Purification and Characterization of the Blue-green RatPhaeochromocytoma PC12. Tyrosine Hydroxylase with a Dopamine-FeIII.Complex", Andersson, K. K.; Vassort, C.; Brennan, B. A.; Que, J., L.;Wallick, D. E. Biochem. J. 1992, 284, 687-695.
37. "Model Complexes for a-Keto Acid-Dependent Enzymes. Structure andReactivity of   {FeII[tris[6-methyl-2-pyridyl.methyl]amine]benzoylformate.]ClO4.", Chiou,Y.-M.;  Que, L., Jr. J. Am. Chem. Soc. 1992, 114, 7567-7568.
38. "EPR Studies of a Dinickel Complex in Its II,II and II,III OxidationStates", Holman, T. R.; Hendrich, M. P.; Que, L., Jr. Inorg. Chem. 1992,31, 937-939. 39. "2D NMR", Ming, L.-J.; Jang, H. G.; Que, L., Jr.Inorg. Chem. 1992, 31, 359-364.
40."Resonance Raman Studies of the Protocatechuate 3,4-Dioxygenasefrom    Brevibacterium fuscum", Siu, D. C.-T.; Orville, A.M.; Lipscomb, J. D.; Ohlendorf, D. H.; Que, L., Jr. Biochemistry 1992, 31,10443-10448.


 
 [1989-1976]   (Please click)